A randomized controlled trial to evaluate short-term treatment with eosin vs. topical steroids in psoriasis

S. Tabolli, L. Alessandroni, B. Didona, C. Di Pietro, P. Gisondi, L. Rota, F. Sampogna, D. Abeni

Research output: Contribution to journalArticle

Abstract

Background: The therapeutic effects of some histological staining agents on psoriasis have been reported in the past. One of these agents is eosin, which is still currently used in routine treatment, although it has never been formally tested in a randomized controlled trial. Aim: To compare treatment with eosin in patients with moderate to severe psoriasis vs. short-course topical steroid, a well-defined, evidence-based treatment. Methods: A randomized trial was designed and conducted. The Skindex-29 and General Health Questionnaire (GHQ)-12 questionnaires, and Psoriasis Activity and Disease Index (PASI) were used before treatment in 43 patients. Five days after treatment, PASI was measured again. Results: Five days after treatment, a significant mean reduction of PASI was observed in both groups: 6.8 (95% CI 5.5-8) for eosin, and 5.2 (3.2-7.1) for steroids. The difference between the two groups was not significant (P = 0.161). Conclusions: Eosin has a short-term effect similar to topical steroids. The low cost of eosin treatment and its limited collateral effects suggest that eosin could be an effective steroid-sparing agent in the initial phase of psoriasis treatment.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalClinical and Experimental Dermatology
Volume34
Issue number3
DOIs
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Dermatology

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