A randomized, double-blind, placebo-controlled study to evaluate the effectiveness of a food supplement containing creatine and d-ribose combined with a physical exercise program in increasing stress tolerance in patients with ischemic heart disease

Giuseppe Derosa, Silvia Pasqualotto, Gabriele Catena, Angela D’angelo, Antonio Maggi, Pamela Maffioli

Research output: Contribution to journalArticle

Abstract

The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.

Original languageEnglish
Article number3075
JournalNutrients
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Cardiovascular disease
  • Creatine
  • D-ribose

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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