TY - JOUR
T1 - A randomized, double-blind, placebo-controlled study to evaluate the effectiveness of a food supplement containing creatine and d-ribose combined with a physical exercise program in increasing stress tolerance in patients with ischemic heart disease
AU - Derosa, Giuseppe
AU - Pasqualotto, Silvia
AU - Catena, Gabriele
AU - D’angelo, Angela
AU - Maggi, Antonio
AU - Maffioli, Pamela
PY - 2019/12
Y1 - 2019/12
N2 - The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.
AB - The aim of this study is to establish whether a supplement of creatine and ribose combined with a physical exercise program can improve the total work capacity during exercise in a population of patients with known ischemic heart disease. A double-blind, six-month study was designed in which 53 patients were enrolled and randomized to take either a nutraceutical composition containing creatine, D-ribose, vitamin B1, and vitamin B6 (active treatment) or the placebo. Both the nutraceutical supplement and the placebo were supplied by Giellepi S.p.A. Health Science in Lissone, Italy. After six months of study, the cardiac double product at the peak of the load, the delta double product, and the chronotropic index were higher in the active treatment group than in the placebo group. We can conclude that a supplementation with creatine, D-ribose, vitamin B1, and vitamin B6, in addition to standard therapy and a physical exercise program, seems to be helpful in improving exercise tolerance compared to the placebo in a population with cardiovascular disease. However, this needs to be further studied, given that there is no clear evidence that the double product can be used as a surrogate measure of exercise tolerance.
KW - Cardiovascular disease
KW - Creatine
KW - D-ribose
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UR - http://www.scopus.com/inward/citedby.url?scp=85076996046&partnerID=8YFLogxK
U2 - 10.3390/nu11123075
DO - 10.3390/nu11123075
M3 - Article
C2 - 31861049
AN - SCOPUS:85076996046
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 12
M1 - 3075
ER -