A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis

G. Alicandro, N. Faelli, R. Gagliardini, B. Santini, G. Magazzù, A. Biffi, P. Risé, C. Galli, A. S. Tirelli, S. Loi, L. Valmarana, N. Cirilli, T. Palmas, G. Vieni, M. L. Bianchi, C. Agostoni, C. Colombo

Research output: Contribution to journalArticle

Abstract

Low plasma concentrations of docosahexaenoic acid (DHA) are reported in unsupplemented cystic fibrosis (CF) patients. Forty-one CF patients aged from 6 to 12 years were randomized to receive high-dose DHA (100. mg/kg/day in the first month and 1. g per day thereafter through a 12-month supplementation) or placebo (germ oil). Primary outcome was percentage change in plasma AA:DHA ratio. Secondary outcomes were changes in the number of pulmonary exacerbations compared to previous year, lung function, BMI, skinfold thicknesses, and body composition assessed by DXA and in serum concentrations of C-reactive protein, cytokines and vitamin (α-tocopherol and retinol). Compared to the control group plasma AA:DHA ratio decreased in the intervention group after 6 months (median percentage changes: -73% in the intervention group vs. -10% in the control group, P=0.001). No differences were detected between groups for secondary outcomes. Despite a decrease of the AA/DHA ratio, DHA supplementation for one year did not induce any significant biochemical and clinical improvement in CF patients.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume88
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cystic fibrosis
  • Docosahexaenoic acid
  • Plasma fatty acids
  • Randomised clinical trial
  • Supplementation

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

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