Abstract
To examine whether long-term consumption of fermented milk containing a specific Lactobacillus casei may improve the health status of preschool children suffering from allergic asthma and/or rhinitis a randomized, prospective, double blind, controlled trial was conducted in 187 children 2-5 y of age. The children received for 12 mo either fermented milk (100 mL) containing Lactobacillus casei (10 cfu/mL) or placebo. The time free from and the number of episodes of asthma/rhinitis after starting intervention were the outcome measures. The number of fever or diarrhea episodes and the change in serum immunoglobulin were further assessed. No statistical difference between intervention and control group occurred in asthmatic children. In children with rhinitis, the annual number of rhinitis episodes was lower in the intervention group, mean difference (95% CI), -1.6 (-3.15 to -0.05); the mean duration of an episode of diarrhea was lower in the intervention group, mean difference -0.81 (-1.52 to -0.10) days. While long-term consumption of fermented milk containing Lactobacillus casei may improve the health status of children with allergic rhinitis no effect was found in asthmatic children.
| Original language | English |
|---|---|
| Pages (from-to) | 215-220 |
| Number of pages | 6 |
| Journal | Pediatric Research |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. / Giovannini, Marcello; Agostoni, Carlo; Riva, Enrica; Salvini, Filippo; Ruscitto, Antonia; Zuccotti, Gian Vincenzo; Radaelli, Giovanni; Besana, R.; Biasucci, G.; Galluzzo, C.; Longhi, R.; Podestà, A.; Sterpa, A.
In: Pediatric Research, Vol. 62, No. 2, 08.2007, p. 215-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis
AU - Giovannini, Marcello
AU - Agostoni, Carlo
AU - Riva, Enrica
AU - Salvini, Filippo
AU - Ruscitto, Antonia
AU - Zuccotti, Gian Vincenzo
AU - Radaelli, Giovanni
AU - Besana, R.
AU - Biasucci, G.
AU - Galluzzo, C.
AU - Longhi, R.
AU - Podestà, A.
AU - Sterpa, A.
PY - 2007/8
Y1 - 2007/8
N2 - To examine whether long-term consumption of fermented milk containing a specific Lactobacillus casei may improve the health status of preschool children suffering from allergic asthma and/or rhinitis a randomized, prospective, double blind, controlled trial was conducted in 187 children 2-5 y of age. The children received for 12 mo either fermented milk (100 mL) containing Lactobacillus casei (10 cfu/mL) or placebo. The time free from and the number of episodes of asthma/rhinitis after starting intervention were the outcome measures. The number of fever or diarrhea episodes and the change in serum immunoglobulin were further assessed. No statistical difference between intervention and control group occurred in asthmatic children. In children with rhinitis, the annual number of rhinitis episodes was lower in the intervention group, mean difference (95% CI), -1.6 (-3.15 to -0.05); the mean duration of an episode of diarrhea was lower in the intervention group, mean difference -0.81 (-1.52 to -0.10) days. While long-term consumption of fermented milk containing Lactobacillus casei may improve the health status of children with allergic rhinitis no effect was found in asthmatic children.
AB - To examine whether long-term consumption of fermented milk containing a specific Lactobacillus casei may improve the health status of preschool children suffering from allergic asthma and/or rhinitis a randomized, prospective, double blind, controlled trial was conducted in 187 children 2-5 y of age. The children received for 12 mo either fermented milk (100 mL) containing Lactobacillus casei (10 cfu/mL) or placebo. The time free from and the number of episodes of asthma/rhinitis after starting intervention were the outcome measures. The number of fever or diarrhea episodes and the change in serum immunoglobulin were further assessed. No statistical difference between intervention and control group occurred in asthmatic children. In children with rhinitis, the annual number of rhinitis episodes was lower in the intervention group, mean difference (95% CI), -1.6 (-3.15 to -0.05); the mean duration of an episode of diarrhea was lower in the intervention group, mean difference -0.81 (-1.52 to -0.10) days. While long-term consumption of fermented milk containing Lactobacillus casei may improve the health status of children with allergic rhinitis no effect was found in asthmatic children.
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U2 - 10.1203/PDR.0b013e3180a76d94
DO - 10.1203/PDR.0b013e3180a76d94
M3 - Article
VL - 62
SP - 215
EP - 220
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 2
ER -