A randomized prospective trial comparing cyclosporine monotherapy with triple-drug therapy in renal transplantation

Antonio Tarantino, Adriana Aroldi, Laura Stucchi, Giuseppe Montagnino, Luca Mascaretti, Antonio Vegeto, Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

In a prospective trial 151 recipients of renal transplants were randomly assigned to treatment with CsA alone (74 patients) and to low dose of AZA, prednisolone, and CsA (77 patients). At two years, graft survival was 84% for the monotherapy and 90% for the triple therapy This difference was not statistically significant. The number of rejection episodes was similar in the two groups, but the severity of rejection was significantly worse among the patients on monotherapy. More kidneys were lost because of rejection (6 versus 3), and a higher number of methylprednisolone pulses was used for treating rejection (5.2±2.3 versus 4.3±2.9; P=0.0077). CsA nephrotoxicity episodes were more frequent among patients on monotherapy (23 versus 7; P

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalTransplantation
Volume52
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Tarantino, A., Aroldi, A., Stucchi, L., Montagnino, G., Mascaretti, L., Vegeto, A., & Ponticelli, C. (1991). A randomized prospective trial comparing cyclosporine monotherapy with triple-drug therapy in renal transplantation. Transplantation, 52(1), 53-57.