A randomized study comparing filgrastim versus lenograstim versus molgramostim plus chemotherapy for peripheral blood progenitor cell mobilization

B. Kopf, U. De Giorgi, B. Vertogen, G. Monti, A. Molinari, D. Turci, C. Dazzi, M. Leoni, A. Tienghi, A. Cariello, M. Argnani, L. Frassineti, E. Scarpi, G. Rosti, M. Marangolo

Research output: Contribution to journalArticle

Abstract

We conducted a prospective randomized clinical trial to assess the mobilizing efficacy of filgrastim, lenograstim and molgramostim following a disease-specific chemotherapy regimen. Mobilization consisted of high-dose cyclophosphamide in 45 cases (44%), and cisplatin/ ifosfamide/etoposide or vinblastine in 22 (21%), followed by randomization to either filgrastim or lenograstim or molgramostim at 5μg/kg/day. One hundred and three patients were randomized, and 82 (79%) performed apheresis. Forty-four (43%) patients were chemonaive, whereas 59 (57%) were pretreated. A median number of one apheresis per patient (range, 1-3) was performed. The median number of CD34+ cells obtained after mobilization was 8.4 × 106/kg in the filgrastim arm versus 5.8 × 106/kg in the lenograstim arm versus 4.0 × 106/kg in the molgramostim arm (P=0.1). A statistically significant difference was observed for the median number of days of growth factor administration in favor of lenograstim (12 days) versus filgrastim (13 days) and molgramostim (14 days) (P

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalBone Marrow Transplantation
Volume38
Issue number6
DOIs
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Kopf, B., De Giorgi, U., Vertogen, B., Monti, G., Molinari, A., Turci, D., Dazzi, C., Leoni, M., Tienghi, A., Cariello, A., Argnani, M., Frassineti, L., Scarpi, E., Rosti, G., & Marangolo, M. (2006). A randomized study comparing filgrastim versus lenograstim versus molgramostim plus chemotherapy for peripheral blood progenitor cell mobilization. Bone Marrow Transplantation, 38(6), 407-412. https://doi.org/10.1038/sj.bmt.1705465