A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism

P. Evenepoel, K. Cooper, H. Holdaas, P. Messa, G. Mourad, K. Olgaard, B. Rutkowski, H. Schaefer, H. Deng, J. V. Torregrosa, R. P. Wuthrich, S. Yue

Research output: Contribution to journalArticle

Abstract

Persistent hyperparathyroidism (HPT) after kidney transplantation (KTx) is associated with hypercalcemia, hypophosphatemia and abnormally high levels of parathyroid hormone (PTH). In this randomized trial, cinacalcet was compared to placebo for the treatment of hypercalcemia in adult patients with persistent HPT after KTx. Subjects were randomized 1:1 to cinacalcet or placebo with randomization stratified by baseline corrected total serum calcium levels (≤11.2 mg/dL [2.80 mmol/L] or >11.2 mg/dL [2.80 mmol/L]). The primary end point was achievement of a mean corrected total serum calcium value

Original languageEnglish
Pages (from-to)2545-2555
Number of pages11
JournalAmerican Journal of Transplantation
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Clinical research/practice
  • hyperparathyrodism
  • kidney disease
  • kidney disease: metabolic
  • kidney transplantation/nephrology
  • kidney transplantation: living donor

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)
  • Medicine(all)

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  • Cite this

    Evenepoel, P., Cooper, K., Holdaas, H., Messa, P., Mourad, G., Olgaard, K., Rutkowski, B., Schaefer, H., Deng, H., Torregrosa, J. V., Wuthrich, R. P., & Yue, S. (2014). A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism. American Journal of Transplantation, 14(11), 2545-2555. https://doi.org/10.1111/ajt.12911