A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia: a report of the Italian Cooperative Group GIMEMA

E. Mandelli, M. L. Vegna, G. Awisati, S. Amadori, A. Spadea, E. Cacciola, N. Cantore, A. De Laurenzi, C. De Rosa, G. Fioritoni, A. Gabbas, V. Liso, C. Malleo, E. Miraglia, M. Montillo, R. Perricone, A. Peta, F. Ricduti, M. C. Petti

Research output: Contribution to journalArticle

Abstract

The Italian Co-operative Group GIMEMA conducted a randomized trial in adult acute nonlymphocytic leukemia (ANLL) to assess the role of postconsolidation treatment. Of 448 evaluable patients entered into the study, 305 (68%) achieved a complete remission after a standard induction with daunorubicin and cytosine arabinoside (3+7; 2+5). Those in remission after a consolidation therapy including 4 courses of daunorubicin, cytosine arabinoside, and 6-thioguanine (DAT) were allocated to one of three arms: no treatment, conventional maintenance, or intensive postconsolidation therapy. The median disease-free survival (DFS) was 13 months, and the median survival was 14 months, with 26% surviving at 6.5 years. There was no difference in survival and in disease-free survival among the three postconsolidation arms. In conclusion our study, as others, suggests that the critical period of ANLL treatment is within the first 5-6 months.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalAnnals of Hematology
Volume64
Issue number4
DOIs
Publication statusPublished - Apr 1992

Keywords

  • Adult acute nonlymphocytic leukemia
  • Chemotherapy
  • Post-consolidation approaches

ASJC Scopus subject areas

  • Hematology

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    Mandelli, E., Vegna, M. L., Awisati, G., Amadori, S., Spadea, A., Cacciola, E., Cantore, N., De Laurenzi, A., De Rosa, C., Fioritoni, G., Gabbas, A., Liso, V., Malleo, C., Miraglia, E., Montillo, M., Perricone, R., Peta, A., Ricduti, F., & Petti, M. C. (1992). A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia: a report of the Italian Cooperative Group GIMEMA. Annals of Hematology, 64(4), 166-172. https://doi.org/10.1007/BF01696218