A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia: a report of the Italian Cooperative Group GIMEMA

E. Mandelli, M. L. Vegna, G. Awisati, S. Amadori, A. Spadea, E. Cacciola, N. Cantore, A. De Laurenzi, C. De Rosa, G. Fioritoni, A. Gabbas, V. Liso, C. Malleo, E. Miraglia, M. Montillo, R. Perricone, A. Peta, F. Ricduti, M. C. Petti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The Italian Co-operative Group GIMEMA conducted a randomized trial in adult acute nonlymphocytic leukemia (ANLL) to assess the role of postconsolidation treatment. Of 448 evaluable patients entered into the study, 305 (68%) achieved a complete remission after a standard induction with daunorubicin and cytosine arabinoside (3+7; 2+5). Those in remission after a consolidation therapy including 4 courses of daunorubicin, cytosine arabinoside, and 6-thioguanine (DAT) were allocated to one of three arms: no treatment, conventional maintenance, or intensive postconsolidation therapy. The median disease-free survival (DFS) was 13 months, and the median survival was 14 months, with 26% surviving at 6.5 years. There was no difference in survival and in disease-free survival among the three postconsolidation arms. In conclusion our study, as others, suggests that the critical period of ANLL treatment is within the first 5-6 months.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalAnnals of Hematology
Volume64
Issue number4
DOIs
Publication statusPublished - Apr 1992

Fingerprint

Leukemia
Daunorubicin
Cytarabine
Acute Myeloid Leukemia
Disease-Free Survival
Thioguanine
Therapeutics
Survival
Maintenance

Keywords

  • Adult acute nonlymphocytic leukemia
  • Chemotherapy
  • Post-consolidation approaches

ASJC Scopus subject areas

  • Hematology

Cite this

A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia : a report of the Italian Cooperative Group GIMEMA. / Mandelli, E.; Vegna, M. L.; Awisati, G.; Amadori, S.; Spadea, A.; Cacciola, E.; Cantore, N.; De Laurenzi, A.; De Rosa, C.; Fioritoni, G.; Gabbas, A.; Liso, V.; Malleo, C.; Miraglia, E.; Montillo, M.; Perricone, R.; Peta, A.; Ricduti, F.; Petti, M. C.

In: Annals of Hematology, Vol. 64, No. 4, 04.1992, p. 166-172.

Research output: Contribution to journalArticle

Mandelli, E, Vegna, ML, Awisati, G, Amadori, S, Spadea, A, Cacciola, E, Cantore, N, De Laurenzi, A, De Rosa, C, Fioritoni, G, Gabbas, A, Liso, V, Malleo, C, Miraglia, E, Montillo, M, Perricone, R, Peta, A, Ricduti, F & Petti, MC 1992, 'A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia: a report of the Italian Cooperative Group GIMEMA', Annals of Hematology, vol. 64, no. 4, pp. 166-172. https://doi.org/10.1007/BF01696218
Mandelli, E. ; Vegna, M. L. ; Awisati, G. ; Amadori, S. ; Spadea, A. ; Cacciola, E. ; Cantore, N. ; De Laurenzi, A. ; De Rosa, C. ; Fioritoni, G. ; Gabbas, A. ; Liso, V. ; Malleo, C. ; Miraglia, E. ; Montillo, M. ; Perricone, R. ; Peta, A. ; Ricduti, F. ; Petti, M. C. / A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia : a report of the Italian Cooperative Group GIMEMA. In: Annals of Hematology. 1992 ; Vol. 64, No. 4. pp. 166-172.
@article{a922d257422b46ed9c161ddf2d60f125,
title = "A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia: a report of the Italian Cooperative Group GIMEMA",
abstract = "The Italian Co-operative Group GIMEMA conducted a randomized trial in adult acute nonlymphocytic leukemia (ANLL) to assess the role of postconsolidation treatment. Of 448 evaluable patients entered into the study, 305 (68{\%}) achieved a complete remission after a standard induction with daunorubicin and cytosine arabinoside (3+7; 2+5). Those in remission after a consolidation therapy including 4 courses of daunorubicin, cytosine arabinoside, and 6-thioguanine (DAT) were allocated to one of three arms: no treatment, conventional maintenance, or intensive postconsolidation therapy. The median disease-free survival (DFS) was 13 months, and the median survival was 14 months, with 26{\%} surviving at 6.5 years. There was no difference in survival and in disease-free survival among the three postconsolidation arms. In conclusion our study, as others, suggests that the critical period of ANLL treatment is within the first 5-6 months.",
keywords = "Adult acute nonlymphocytic leukemia, Chemotherapy, Post-consolidation approaches",
author = "E. Mandelli and Vegna, {M. L.} and G. Awisati and S. Amadori and A. Spadea and E. Cacciola and N. Cantore and {De Laurenzi}, A. and {De Rosa}, C. and G. Fioritoni and A. Gabbas and V. Liso and C. Malleo and E. Miraglia and M. Montillo and R. Perricone and A. Peta and F. Ricduti and Petti, {M. C.}",
year = "1992",
month = "4",
doi = "10.1007/BF01696218",
language = "English",
volume = "64",
pages = "166--172",
journal = "Annals of Hematology",
issn = "0939-5555",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - A randomized study of the efficacy of postconsolidation therapy in adult acute nonly mphocytic leukemia

T2 - a report of the Italian Cooperative Group GIMEMA

AU - Mandelli, E.

AU - Vegna, M. L.

AU - Awisati, G.

AU - Amadori, S.

AU - Spadea, A.

AU - Cacciola, E.

AU - Cantore, N.

AU - De Laurenzi, A.

AU - De Rosa, C.

AU - Fioritoni, G.

AU - Gabbas, A.

AU - Liso, V.

AU - Malleo, C.

AU - Miraglia, E.

AU - Montillo, M.

AU - Perricone, R.

AU - Peta, A.

AU - Ricduti, F.

AU - Petti, M. C.

PY - 1992/4

Y1 - 1992/4

N2 - The Italian Co-operative Group GIMEMA conducted a randomized trial in adult acute nonlymphocytic leukemia (ANLL) to assess the role of postconsolidation treatment. Of 448 evaluable patients entered into the study, 305 (68%) achieved a complete remission after a standard induction with daunorubicin and cytosine arabinoside (3+7; 2+5). Those in remission after a consolidation therapy including 4 courses of daunorubicin, cytosine arabinoside, and 6-thioguanine (DAT) were allocated to one of three arms: no treatment, conventional maintenance, or intensive postconsolidation therapy. The median disease-free survival (DFS) was 13 months, and the median survival was 14 months, with 26% surviving at 6.5 years. There was no difference in survival and in disease-free survival among the three postconsolidation arms. In conclusion our study, as others, suggests that the critical period of ANLL treatment is within the first 5-6 months.

AB - The Italian Co-operative Group GIMEMA conducted a randomized trial in adult acute nonlymphocytic leukemia (ANLL) to assess the role of postconsolidation treatment. Of 448 evaluable patients entered into the study, 305 (68%) achieved a complete remission after a standard induction with daunorubicin and cytosine arabinoside (3+7; 2+5). Those in remission after a consolidation therapy including 4 courses of daunorubicin, cytosine arabinoside, and 6-thioguanine (DAT) were allocated to one of three arms: no treatment, conventional maintenance, or intensive postconsolidation therapy. The median disease-free survival (DFS) was 13 months, and the median survival was 14 months, with 26% surviving at 6.5 years. There was no difference in survival and in disease-free survival among the three postconsolidation arms. In conclusion our study, as others, suggests that the critical period of ANLL treatment is within the first 5-6 months.

KW - Adult acute nonlymphocytic leukemia

KW - Chemotherapy

KW - Post-consolidation approaches

UR - http://www.scopus.com/inward/record.url?scp=0026593794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026593794&partnerID=8YFLogxK

U2 - 10.1007/BF01696218

DO - 10.1007/BF01696218

M3 - Article

C2 - 1581404

AN - SCOPUS:0026593794

VL - 64

SP - 166

EP - 172

JO - Annals of Hematology

JF - Annals of Hematology

SN - 0939-5555

IS - 4

ER -