A randomized trial comparing triple-drug and double-drug therapy in renal transplantation

C. Ponticelli, A. Tarantino, G. Montagnino, A. Aroldi, G. Banfi, A. De Vecchi, R. Zubani, L. Berardinelli, A. Vegeto

Research output: Contribution to journalArticle

Abstract

A controlled trial was carried out in 86 cadaveric and 14 living haploidentical renal transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (Aza) and steroids with those of higher doses of CsA plus steroids. Patients were followed for 12-26 months after transplantation. The actuarial 2- year patient and graft survival rate was 100% for living-donor transplants. In cadaver renal transplants the 2-year patient survival rate was 100% for patients assigned to the triple regimen and 93% for those allocated to the double regimen. The actuarial 2-year cadaver graft survival rates were 86% and 90.6%, respectively. There were significantly more patients who had severe infections (P

Original languageEnglish
Pages (from-to)913-918
Number of pages6
JournalTransplantation
Volume45
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Ponticelli, C., Tarantino, A., Montagnino, G., Aroldi, A., Banfi, G., Vecchi, A. D., Zubani, R., Berardinelli, L., & Vegeto, A. (1988). A randomized trial comparing triple-drug and double-drug therapy in renal transplantation. Transplantation, 45(5), 913-918.