A randomized trial comparing triple-drug and double-drug therapy in renal transplantation: Analysis at 7 years

G. Montagnino, A. Tarantino, G. Banfi, A. Aroldi, B. Cesana, C. Ponticelli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This is the 7-year update of a randomized trial comparing triple (TT) and double (DT) immunosuppressive therapy in renal transplantation. At 7 years, patient survival rate was 85% in DT vs. 87% in TT (P=NS); graft survival rate was 73% in DT and 68% in TT (P=NS); pure graft survival was 86% in DT vs. 77% in TT (P=0.096). The 7-year graft survival rate was 67% for cadaver graft recipients vs. 92% for living-related graft recipients (P=0.044). No difference in the slopes of plasma creatinine between the two groups was observed. Ten DT and 13 TT patients changed their original therapy: statistical analysis, however, was carried out according to intention to treat. Both CsA levels and doses were significantly higher in DT than in TT group (P

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalTransplantation
Volume58
Issue number2
Publication statusPublished - 1994

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Graft Survival
Kidney Transplantation
Survival Rate
Drug Therapy
Pharmaceutical Preparations
Transplants
Immunosuppressive Agents
Cadaver
Creatinine
Therapeutics

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Montagnino, G., Tarantino, A., Banfi, G., Aroldi, A., Cesana, B., & Ponticelli, C. (1994). A randomized trial comparing triple-drug and double-drug therapy in renal transplantation: Analysis at 7 years. Transplantation, 58(2), 149-154.

A randomized trial comparing triple-drug and double-drug therapy in renal transplantation : Analysis at 7 years. / Montagnino, G.; Tarantino, A.; Banfi, G.; Aroldi, A.; Cesana, B.; Ponticelli, C.

In: Transplantation, Vol. 58, No. 2, 1994, p. 149-154.

Research output: Contribution to journalArticle

Montagnino, G, Tarantino, A, Banfi, G, Aroldi, A, Cesana, B & Ponticelli, C 1994, 'A randomized trial comparing triple-drug and double-drug therapy in renal transplantation: Analysis at 7 years', Transplantation, vol. 58, no. 2, pp. 149-154.
Montagnino G, Tarantino A, Banfi G, Aroldi A, Cesana B, Ponticelli C. A randomized trial comparing triple-drug and double-drug therapy in renal transplantation: Analysis at 7 years. Transplantation. 1994;58(2):149-154.
Montagnino, G. ; Tarantino, A. ; Banfi, G. ; Aroldi, A. ; Cesana, B. ; Ponticelli, C. / A randomized trial comparing triple-drug and double-drug therapy in renal transplantation : Analysis at 7 years. In: Transplantation. 1994 ; Vol. 58, No. 2. pp. 149-154.
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