A randomized trial for the treatment of high-grade soft-tissue sarcomas of the extremities: Preliminary observations

F. Gherlinzoni, G. Bacci, P. Picci, R. Capanna, P. Calderoni, E. G. Lorenzi, M. Bernini, E. Emiliani, E. Barbieri, A. Normand

Research output: Contribution to journalArticlepeer-review

Abstract

A new trial for evaluating the effectiveness of adjuvant chemotherapy in high-grade soft-tissue sarcomas of the extremities in adult patients is presented. All patients after local treatment were randomized into two arms, one without further therapy and the other to receive adjuvant chemotherapy (Adriamycin [Farmitalia-Carlo Erba, Milan, Italy], 450 mg/m2). The preliminary results of the study are reported at a median observation period of 27.6 months. Of the 59 patients who entered the study, 79.1% in the chemotherapy group are without sign of disease, whereas the corresponding figure in the nonadjuvant chemotherapy group is 54.3%. The difference between the two groups is statistically significant (P <.005, log rank test). These preliminary observations encourage continuation of the study.

Original languageEnglish
Pages (from-to)552-558
Number of pages7
JournalJournal of Clinical Oncology
Volume4
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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