A randomized trial of factor VIII and neutralizing antibodies in hemophilia A

F. Peyvandi; P. M. Mannucci; I. Garagiola; A. El-Beshlawy; M. Elalfy; V. Ramanan; P. Eshghi; S. Hanagavadi; R. Varadarajan; M. Karimi; M. V. Manglani; C. Ross; G. Young; T. Seth; S. Apte; D. M. Nayak; E. Santagostino; M. E. Mancuso; A. C. Sandoval Gonzalez; J. N. Mahlangu; S. Bonanad Boix; M. Cerqueira; N. P. Ewing; C. Male; T. Owaidah; Soto V. Arellano; N. L. Kobrinsky; S. Majumdar; R. Perez Garrido; A. Sachdeva; M. Simpson; M. Thomas; E. Zanon; B. Antmen; K. Kavakli; M. J. Manco-Johnson; M. Martinez; E. Marzouka; M. G. Mazzucconi; D. Neme; A. Palomo Bravo; R. Paredes Aguilera; A. Prezotti; K. Schmitt; B. M. Wicklund; B. Zulfikar; F. R. Rosendaal

doi:10.1056/NEJMoa1516437

A randomized trial of factor VIII and neutralizing antibodies in hemophilia A

F. Peyvandi, P. M. Mannucci, I. Garagiola, A. El-Beshlawy, M. Elalfy, V. Ramanan, P. Eshghi, S. Hanagavadi, R. Varadarajan, M. Karimi, M. V. Manglani, C. Ross, G. Young, T. Seth, S. Apte, D. M. Nayak, E. Santagostino, M. E. Mancuso, A. C. Sandoval Gonzalez, J. N. MahlanguS. Bonanad Boix, M. Cerqueira, N. P. Ewing, C. Male, T. Owaidah, Soto V. Arellano, N. L. Kobrinsky, S. Majumdar, R. Perez Garrido, A. Sachdeva, M. Simpson, M. Thomas, E. Zanon, B. Antmen, K. Kavakli, M. J. Manco-Johnson, M. Martinez, E. Marzouka, M. G. Mazzucconi, D. Neme, A. Palomo Bravo, R. Paredes Aguilera, A. Prezotti, K. Schmitt, B. M. Wicklund, B. Zulfikar, F. R. Rosendaal

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

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Abstract

BACKGROUND: The development of neutralizing anti-factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy. METHODS We conducted a randomized trial to assess the incidence of factor VIII inhibitors among patients treated with plasma-derived factor VIII containing von Willebrand factor or recombinant factor VIII. Patients who met the eligibility criteria (male sex, age

Original language	English
Pages (from-to)	2054-2064
Number of pages	11
Journal	New England Journal of Medicine
Volume	374
Issue number	21
DOIs	https://doi.org/10.1056/NEJMoa1516437
Publication status	Published - May 26 2016

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Medicine(all)

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Peyvandi, F., Mannucci, P. M., Garagiola, I., El-Beshlawy, A., Elalfy, M., Ramanan, V., Eshghi, P., Hanagavadi, S., Varadarajan, R., Karimi, M., Manglani, M. V., Ross, C., Young, G., Seth, T., Apte, S., Nayak, D. M., Santagostino, E., Mancuso, M. E., Sandoval Gonzalez, A. C., ... Rosendaal, F. R. (2016). A randomized trial of factor VIII and neutralizing antibodies in hemophilia A. New England Journal of Medicine, 374(21), 2054-2064. https://doi.org/10.1056/NEJMoa1516437

A randomized trial of factor VIII and neutralizing antibodies in hemophilia A. / Peyvandi, F.; Mannucci, P. M.; Garagiola, I.; El-Beshlawy, A.; Elalfy, M.; Ramanan, V.; Eshghi, P.; Hanagavadi, S.; Varadarajan, R.; Karimi, M.; Manglani, M. V.; Ross, C.; Young, G.; Seth, T.; Apte, S.; Nayak, D. M.; Santagostino, E.; Mancuso, M. E.; Sandoval Gonzalez, A. C.; Mahlangu, J. N.; Bonanad Boix, S.; Cerqueira, M.; Ewing, N. P.; Male, C.; Owaidah, T.; Arellano, Soto V.; Kobrinsky, N. L.; Majumdar, S.; Perez Garrido, R.; Sachdeva, A.; Simpson, M.; Thomas, M.; Zanon, E.; Antmen, B.; Kavakli, K.; Manco-Johnson, M. J.; Martinez, M.; Marzouka, E.; Mazzucconi, M. G.; Neme, D.; Palomo Bravo, A.; Paredes Aguilera, R.; Prezotti, A.; Schmitt, K.; Wicklund, B. M.; Zulfikar, B.; Rosendaal, F. R.

In: New England Journal of Medicine, Vol. 374, No. 21, 26.05.2016, p. 2054-2064.

Research output: Contribution to journal › Article › peer-review

Peyvandi, F , Mannucci, PM, Garagiola, I, El-Beshlawy, A, Elalfy, M, Ramanan, V, Eshghi, P, Hanagavadi, S, Varadarajan, R, Karimi, M, Manglani, MV, Ross, C, Young, G, Seth, T, Apte, S, Nayak, DM, Santagostino, E, Mancuso, ME, Sandoval Gonzalez, AC, Mahlangu, JN, Bonanad Boix, S, Cerqueira, M, Ewing, NP, Male, C, Owaidah, T, Arellano, SV, Kobrinsky, NL, Majumdar, S, Perez Garrido, R, Sachdeva, A, Simpson, M, Thomas, M, Zanon, E, Antmen, B, Kavakli, K, Manco-Johnson, MJ, Martinez, M, Marzouka, E, Mazzucconi, MG, Neme, D, Palomo Bravo, A, Paredes Aguilera, R, Prezotti, A, Schmitt, K, Wicklund, BM, Zulfikar, B & Rosendaal, FR 2016, 'A randomized trial of factor VIII and neutralizing antibodies in hemophilia A', New England Journal of Medicine, vol. 374, no. 21, pp. 2054-2064. https://doi.org/10.1056/NEJMoa1516437

Peyvandi, F. ; Mannucci, P. M. ; Garagiola, I. ; El-Beshlawy, A. ; Elalfy, M. ; Ramanan, V. ; Eshghi, P. ; Hanagavadi, S. ; Varadarajan, R. ; Karimi, M. ; Manglani, M. V. ; Ross, C. ; Young, G. ; Seth, T. ; Apte, S. ; Nayak, D. M. ; Santagostino, E. ; Mancuso, M. E. ; Sandoval Gonzalez, A. C. ; Mahlangu, J. N. ; Bonanad Boix, S. ; Cerqueira, M. ; Ewing, N. P. ; Male, C. ; Owaidah, T. ; Arellano, Soto V. ; Kobrinsky, N. L. ; Majumdar, S. ; Perez Garrido, R. ; Sachdeva, A. ; Simpson, M. ; Thomas, M. ; Zanon, E. ; Antmen, B. ; Kavakli, K. ; Manco-Johnson, M. J. ; Martinez, M. ; Marzouka, E. ; Mazzucconi, M. G. ; Neme, D. ; Palomo Bravo, A. ; Paredes Aguilera, R. ; Prezotti, A. ; Schmitt, K. ; Wicklund, B. M. ; Zulfikar, B. ; Rosendaal, F. R. / A randomized trial of factor VIII and neutralizing antibodies in hemophilia A. In: New England Journal of Medicine. 2016 ; Vol. 374, No. 21. pp. 2054-2064.

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abstract = "BACKGROUND: The development of neutralizing anti-factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy. METHODS We conducted a randomized trial to assess the incidence of factor VIII inhibitors among patients treated with plasma-derived factor VIII containing von Willebrand factor or recombinant factor VIII. Patients who met the eligibility criteria (male sex, age ",

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AU - Eshghi, P.

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AU - Apte, S.

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AU - Sandoval Gonzalez, A. C.

AU - Mahlangu, J. N.

AU - Bonanad Boix, S.

AU - Cerqueira, M.

AU - Ewing, N. P.

AU - Male, C.

AU - Owaidah, T.

AU - Arellano, Soto V.

AU - Kobrinsky, N. L.

AU - Majumdar, S.

AU - Perez Garrido, R.

AU - Sachdeva, A.

AU - Simpson, M.

AU - Thomas, M.

AU - Zanon, E.

AU - Antmen, B.

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AU - Mazzucconi, M. G.

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AU - Paredes Aguilera, R.

AU - Prezotti, A.

AU - Schmitt, K.

AU - Wicklund, B. M.

AU - Zulfikar, B.

AU - Rosendaal, F. R.

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A randomized trial of factor VIII and neutralizing antibodies in hemophilia A

Abstract

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