A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria

Carlo Agostoni, Ann Harvie, Daphne L. McCulloch, Colin Demellweek, Forrester Cockburn, Marcello Giovannini, Gordon Murray, R. Angus Harkness, Enrica Riva

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-two infants (20 males, 22 females) with classical phenylketonuria (PKU) entered a prospective, double-blind, randomized study to investigate the effects on biochemical and physiological outcomes of a phenylalanine-free infant formula containing a fat blend supplemented with the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6 n - 3), and arachidonic acid (AA, C20:4 n - 6). Between entry and 20 weeks (entry and 1y) of age, median DHA levels in erythrocyte membrane phospholipids decreased by 15% (22%) in the LC-PUFA supplemented group (n=21) and by 61% (64%) in the control group (p

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalDevelopmental Medicine and Child Neurology
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)

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