TY - JOUR
T1 - A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria
AU - Agostoni, Carlo
AU - Harvie, Ann
AU - McCulloch, Daphne L.
AU - Demellweek, Colin
AU - Cockburn, Forrester
AU - Giovannini, Marcello
AU - Murray, Gordon
AU - Harkness, R. Angus
AU - Riva, Enrica
PY - 2006/3
Y1 - 2006/3
N2 - Forty-two infants (20 males, 22 females) with classical phenylketonuria (PKU) entered a prospective, double-blind, randomized study to investigate the effects on biochemical and physiological outcomes of a phenylalanine-free infant formula containing a fat blend supplemented with the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6 n - 3), and arachidonic acid (AA, C20:4 n - 6). Between entry and 20 weeks (entry and 1y) of age, median DHA levels in erythrocyte membrane phospholipids decreased by 15% (22%) in the LC-PUFA supplemented group (n=21) and by 61% (64%) in the control group (p
AB - Forty-two infants (20 males, 22 females) with classical phenylketonuria (PKU) entered a prospective, double-blind, randomized study to investigate the effects on biochemical and physiological outcomes of a phenylalanine-free infant formula containing a fat blend supplemented with the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6 n - 3), and arachidonic acid (AA, C20:4 n - 6). Between entry and 20 weeks (entry and 1y) of age, median DHA levels in erythrocyte membrane phospholipids decreased by 15% (22%) in the LC-PUFA supplemented group (n=21) and by 61% (64%) in the control group (p
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U2 - 10.1017/S0012162206000442
DO - 10.1017/S0012162206000442
M3 - Article
C2 - 16483397
AN - SCOPUS:33645729181
VL - 48
SP - 207
EP - 212
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
SN - 0012-1622
IS - 3
ER -