A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

M. Tada, R. Iwata, H. Sugiyama, K. Sato, C. Pascali, H. Fukuda, K. Kubota, R. Kubota, H. Takahashi, A. Wakui, Y. Abe, T. Fujiwara, T. Sato, T. Ido

Research output: Contribution to journalArticle

Abstract

An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume33
Issue number7
Publication statusPublished - 1993

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Keywords

  • [F]fluoride
  • [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine
  • Ethyl bromoacetate
  • Ethyl p-toluensulfonyloxyacetate
  • N(Ω)-fluoroacetyl-5-methoxytryptamine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606.