Abstract
An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 601-606 |
| Number of pages | 6 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 33 |
| Issue number | 7 |
| Publication status | Published - 1993 |
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Keywords
- [F]fluoride
- [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine
- Ethyl bromoacetate
- Ethyl p-toluensulfonyloxyacetate
- N(Ω)-fluoroacetyl-5-methoxytryptamine
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Medicine
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606.