A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

M. Tada, R. Iwata, H. Sugiyama, K. Sato, C. Pascali, H. Fukuda, K. Kubota, R. Kubota, H. Takahashi, A. Wakui, Y. Abe, T. Fujiwara, T. Sato, T. Ido

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume33
Issue number7
Publication statusPublished - 1993

Fingerprint

5-Methoxytryptamine
Diagnostic Imaging
Fluorides
Imaging techniques

Keywords

  • [F]fluoride
  • [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine
  • Ethyl bromoacetate
  • Ethyl p-toluensulfonyloxyacetate
  • N(Ω)-fluoroacetyl-5-methoxytryptamine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. / Tada, M.; Iwata, R.; Sugiyama, H.; Sato, K.; Pascali, C.; Fukuda, H.; Kubota, K.; Kubota, R.; Takahashi, H.; Wakui, A.; Abe, Y.; Fujiwara, T.; Sato, T.; Ido, T.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 33, No. 7, 1993, p. 601-606.

Research output: Contribution to journal › Article

Tada, M, Iwata, R, Sugiyama, H, Sato, K, Pascali, C, Fukuda, H, Kubota, K, Kubota, R, Takahashi, H, Wakui, A, Abe, Y, Fujiwara, T, Sato, T & Ido, T 1993, 'A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, no. 7, pp. 601-606.
Tada M, Iwata R, Sugiyama H, Sato K, Pascali C, Fukuda H et al. A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals. 1993;33(7):601-606.
Tada, M. ; Iwata, R. ; Sugiyama, H. ; Sato, K. ; Pascali, C. ; Fukuda, H. ; Kubota, K. ; Kubota, R. ; Takahashi, H. ; Wakui, A. ; Abe, Y. ; Fujiwara, T. ; Sato, T. ; Ido, T. / A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1993 ; Vol. 33, No. 7. pp. 601-606.
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