A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

M. Tada; R. Iwata; H. Sugiyama; K. Sato; C. Pascali; H. Fukuda; K. Kubota; R. Kubota; H. Takahashi; A. Wakui; Y. Abe; T. Fujiwara; T. Sato; T. Ido

A rapid synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (N(Ω)-[¹⁸F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

M. Tada, R. Iwata, H. Sugiyama, K. Sato, C. Pascali, H. Fukuda, K. Kubota, R. Kubota, H. Takahashi, A. Wakui, Y. Abe, T. Fujiwara, T. Sato, T. Ido

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (NΩ)-[¹⁸F]Fluoroacetyl-5-methoxytryptamine) starting from [¹⁸F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

Original language	English
Pages (from-to)	601-606
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	33
Issue number	7
Publication status	Published - 1993

Keywords

[F]fluoride
[Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine
Ethyl bromoacetate
Ethyl p-toluensulfonyloxyacetate
N(Ω)-fluoroacetyl-5-methoxytryptamine

ASJC Scopus subject areas

Clinical Biochemistry
Molecular Medicine
Analytical Chemistry
Organic Chemistry
Drug Discovery
Pharmacology

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Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (N(Ω)-[¹⁸F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606.

A rapid synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (N(Ω)-[¹⁸F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. / Tada, M.; Iwata, R.; Sugiyama, H.; Sato, K.; Pascali, C.; Fukuda, H.; Kubota, K.; Kubota, R.; Takahashi, H.; Wakui, A.; Abe, Y.; Fujiwara, T.; Sato, T.; Ido, T.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 33, No. 7, 1993, p. 601-606.

Research output: Contribution to journal › Article › peer-review

Tada, M, Iwata, R, Sugiyama, H, Sato, K, Pascali, C, Fukuda, H, Kubota, K, Kubota, R, Takahashi, H, Wakui, A, Abe, Y, Fujiwara, T, Sato, T & Ido, T 1993, 'A rapid synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (N(Ω)-[¹⁸F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, no. 7, pp. 601-606.

Tada, M. ; Iwata, R. ; Sugiyama, H. ; Sato, K. ; Pascali, C. ; Fukuda, H. ; Kubota, K. ; Kubota, R. ; Takahashi, H. ; Wakui, A. ; Abe, Y. ; Fujiwara, T. ; Sato, T. ; Ido, T. / A rapid synthesis of [fluoroacetyl-¹⁸F]fluoromelatonin (N(Ω)-[¹⁸F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1993 ; Vol. 33, No. 7. pp. 601-606.

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title = "A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent",

abstract = "An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.",

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author = "M. Tada and R. Iwata and H. Sugiyama and K. Sato and C. Pascali and H. Fukuda and K. Kubota and R. Kubota and H. Takahashi and A. Wakui and Y. Abe and T. Fujiwara and T. Sato and T. Ido",

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AU - Tada, M.

AU - Iwata, R.

AU - Sugiyama, H.

AU - Sato, K.

AU - Pascali, C.

AU - Fukuda, H.

AU - Kubota, K.

AU - Kubota, R.

AU - Takahashi, H.

AU - Wakui, A.

AU - Abe, Y.

AU - Fujiwara, T.

AU - Sato, T.

AU - Ido, T.

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AB - An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

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