A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

M. Tada, R. Iwata, H. Sugiyama, K. Sato, C. Pascali, H. Fukuda, K. Kubota, R. Kubota, H. Takahashi, A. Wakui, Y. Abe, T. Fujiwara, T. Sato, T. Ido

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume33
Issue number7
Publication statusPublished - 1993

Fingerprint

5-Methoxytryptamine
Diagnostic Imaging
Fluorides
Imaging techniques

Keywords

  • [F]fluoride
  • [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine
  • Ethyl bromoacetate
  • Ethyl p-toluensulfonyloxyacetate
  • N(Ω)-fluoroacetyl-5-methoxytryptamine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. / Tada, M.; Iwata, R.; Sugiyama, H.; Sato, K.; Pascali, C.; Fukuda, H.; Kubota, K.; Kubota, R.; Takahashi, H.; Wakui, A.; Abe, Y.; Fujiwara, T.; Sato, T.; Ido, T.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 33, No. 7, 1993, p. 601-606.

Research output: Contribution to journalArticle

Tada, M, Iwata, R, Sugiyama, H, Sato, K, Pascali, C, Fukuda, H, Kubota, K, Kubota, R, Takahashi, H, Wakui, A, Abe, Y, Fujiwara, T, Sato, T & Ido, T 1993, 'A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, no. 7, pp. 601-606.
Tada, M. ; Iwata, R. ; Sugiyama, H. ; Sato, K. ; Pascali, C. ; Fukuda, H. ; Kubota, K. ; Kubota, R. ; Takahashi, H. ; Wakui, A. ; Abe, Y. ; Fujiwara, T. ; Sato, T. ; Ido, T. / A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1993 ; Vol. 33, No. 7. pp. 601-606.
@article{fe8933fc1962487c8e8e4180fc0c471f,
title = "A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent",
abstract = "An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2{\%}, > 98{\%}, and 540 mCi/μmol, respectively.",
keywords = "[F]fluoride, [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine, Ethyl bromoacetate, Ethyl p-toluensulfonyloxyacetate, N(Ω)-fluoroacetyl-5-methoxytryptamine",
author = "M. Tada and R. Iwata and H. Sugiyama and K. Sato and C. Pascali and H. Fukuda and K. Kubota and R. Kubota and H. Takahashi and A. Wakui and Y. Abe and T. Fujiwara and T. Sato and T. Ido",
year = "1993",
language = "English",
volume = "33",
pages = "601--606",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (N(Ω)-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

AU - Tada, M.

AU - Iwata, R.

AU - Sugiyama, H.

AU - Sato, K.

AU - Pascali, C.

AU - Fukuda, H.

AU - Kubota, K.

AU - Kubota, R.

AU - Takahashi, H.

AU - Wakui, A.

AU - Abe, Y.

AU - Fujiwara, T.

AU - Sato, T.

AU - Ido, T.

PY - 1993

Y1 - 1993

N2 - An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

AB - An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (NΩ)-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, > 98%, and 540 mCi/μmol, respectively.

KW - [F]fluoride

KW - [Fluoroacetyl-F]Fluoromelatonin N(Ω)-[F]fluoroacetyl-5-methoxytryptamine

KW - Ethyl bromoacetate

KW - Ethyl p-toluensulfonyloxyacetate

KW - N(Ω)-fluoroacetyl-5-methoxytryptamine

UR - http://www.scopus.com/inward/record.url?scp=0027193933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027193933&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 601

EP - 606

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 7

ER -