A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: Case report and literature review

M. Intra, A. Maggioni, A. Sonzogni, C. De Cicco, L. S. Machado, A. Sagona, N. Talakhadze

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Only 17 cases of breast carcinoma arising in vulvar ectopic mammary tissue have been reported. We present a unique case of synchronous pure intraductal carcinoma of the breast (DCIS) and invasive carcinoma of ectopic breast tissue of the vulva. A 53-year-old woman presented with a 2-cm nodule in left labium major of the vulva. A surgical biopsy revealed an invasive carcinoma of ectopic mammary tissue. The mammography showed irregular microcalcifications of the right breast. The patient underwent left hemivulvectomy, bilateral inguinal sentinel lymph node biopsy, and radioguided breast resection (radioguided occult lesion localization) of the microcalcifications. The definitive histology revealed negative inguinal sentinel nodes, no further residual tumor in the vulva, and a high-grade (grade 3) DCIS in the breast. The synchronous occurrence of primary breast carcinoma and ectopic breast tissue carcinoma in the vulva is an extremely rare finding, only once previously being reported and leading to unsolved problems of differential diagnosis. The presence of a pure DCIS of the breast makes this case really unique, definitively confirming the independent primary origin of both mammary tumors. The inguinal sentinel node biopsy avoided a bilateral inguinal dissection.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume16
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Choristoma
Carcinoma, Intraductal, Noninfiltrating
Vulva
Breast
Breast Neoplasms
Groin
Calcinosis
Biopsy
Sentinel Lymph Node Biopsy
Residual Neoplasm
Mammography
Dissection
Histology
Differential Diagnosis
Carcinoma

Keywords

  • Breast cancer
  • Carcinoma of the vulva
  • DCIS
  • Ectopic breast cancer
  • Inguinal sentinel node biopsy
  • Lymphoscintigraphy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Cancer Research

Cite this

@article{94a9bb4fc4994eff8eb7410a47495d2a,
title = "A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: Case report and literature review",
abstract = "Only 17 cases of breast carcinoma arising in vulvar ectopic mammary tissue have been reported. We present a unique case of synchronous pure intraductal carcinoma of the breast (DCIS) and invasive carcinoma of ectopic breast tissue of the vulva. A 53-year-old woman presented with a 2-cm nodule in left labium major of the vulva. A surgical biopsy revealed an invasive carcinoma of ectopic mammary tissue. The mammography showed irregular microcalcifications of the right breast. The patient underwent left hemivulvectomy, bilateral inguinal sentinel lymph node biopsy, and radioguided breast resection (radioguided occult lesion localization) of the microcalcifications. The definitive histology revealed negative inguinal sentinel nodes, no further residual tumor in the vulva, and a high-grade (grade 3) DCIS in the breast. The synchronous occurrence of primary breast carcinoma and ectopic breast tissue carcinoma in the vulva is an extremely rare finding, only once previously being reported and leading to unsolved problems of differential diagnosis. The presence of a pure DCIS of the breast makes this case really unique, definitively confirming the independent primary origin of both mammary tumors. The inguinal sentinel node biopsy avoided a bilateral inguinal dissection.",
keywords = "Breast cancer, Carcinoma of the vulva, DCIS, Ectopic breast cancer, Inguinal sentinel node biopsy, Lymphoscintigraphy",
author = "M. Intra and A. Maggioni and A. Sonzogni and {De Cicco}, C. and Machado, {L. S.} and A. Sagona and N. Talakhadze",
year = "2006",
month = "2",
doi = "10.1111/j.1525-1438.2006.00237.x",
language = "English",
volume = "16",
pages = "428--433",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 1",

}

TY - JOUR

T1 - A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva

T2 - Case report and literature review

AU - Intra, M.

AU - Maggioni, A.

AU - Sonzogni, A.

AU - De Cicco, C.

AU - Machado, L. S.

AU - Sagona, A.

AU - Talakhadze, N.

PY - 2006/2

Y1 - 2006/2

N2 - Only 17 cases of breast carcinoma arising in vulvar ectopic mammary tissue have been reported. We present a unique case of synchronous pure intraductal carcinoma of the breast (DCIS) and invasive carcinoma of ectopic breast tissue of the vulva. A 53-year-old woman presented with a 2-cm nodule in left labium major of the vulva. A surgical biopsy revealed an invasive carcinoma of ectopic mammary tissue. The mammography showed irregular microcalcifications of the right breast. The patient underwent left hemivulvectomy, bilateral inguinal sentinel lymph node biopsy, and radioguided breast resection (radioguided occult lesion localization) of the microcalcifications. The definitive histology revealed negative inguinal sentinel nodes, no further residual tumor in the vulva, and a high-grade (grade 3) DCIS in the breast. The synchronous occurrence of primary breast carcinoma and ectopic breast tissue carcinoma in the vulva is an extremely rare finding, only once previously being reported and leading to unsolved problems of differential diagnosis. The presence of a pure DCIS of the breast makes this case really unique, definitively confirming the independent primary origin of both mammary tumors. The inguinal sentinel node biopsy avoided a bilateral inguinal dissection.

AB - Only 17 cases of breast carcinoma arising in vulvar ectopic mammary tissue have been reported. We present a unique case of synchronous pure intraductal carcinoma of the breast (DCIS) and invasive carcinoma of ectopic breast tissue of the vulva. A 53-year-old woman presented with a 2-cm nodule in left labium major of the vulva. A surgical biopsy revealed an invasive carcinoma of ectopic mammary tissue. The mammography showed irregular microcalcifications of the right breast. The patient underwent left hemivulvectomy, bilateral inguinal sentinel lymph node biopsy, and radioguided breast resection (radioguided occult lesion localization) of the microcalcifications. The definitive histology revealed negative inguinal sentinel nodes, no further residual tumor in the vulva, and a high-grade (grade 3) DCIS in the breast. The synchronous occurrence of primary breast carcinoma and ectopic breast tissue carcinoma in the vulva is an extremely rare finding, only once previously being reported and leading to unsolved problems of differential diagnosis. The presence of a pure DCIS of the breast makes this case really unique, definitively confirming the independent primary origin of both mammary tumors. The inguinal sentinel node biopsy avoided a bilateral inguinal dissection.

KW - Breast cancer

KW - Carcinoma of the vulva

KW - DCIS

KW - Ectopic breast cancer

KW - Inguinal sentinel node biopsy

KW - Lymphoscintigraphy

UR - http://www.scopus.com/inward/record.url?scp=33645374052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645374052&partnerID=8YFLogxK

U2 - 10.1111/j.1525-1438.2006.00237.x

DO - 10.1111/j.1525-1438.2006.00237.x

M3 - Article

C2 - 16515639

AN - SCOPUS:33645374052

VL - 16

SP - 428

EP - 433

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - SUPPL. 1

ER -