A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: Case report and literature review

M. Intra, A. Maggioni, A. Sonzogni, C. De Cicco, L. S. Machado, A. Sagona, N. Talakhadze

Research output: Contribution to journalArticle

Abstract

Only 17 cases of breast carcinoma arising in vulvar ectopic mammary tissue have been reported. We present a unique case of synchronous pure intraductal carcinoma of the breast (DCIS) and invasive carcinoma of ectopic breast tissue of the vulva. A 53-year-old woman presented with a 2-cm nodule in left labium major of the vulva. A surgical biopsy revealed an invasive carcinoma of ectopic mammary tissue. The mammography showed irregular microcalcifications of the right breast. The patient underwent left hemivulvectomy, bilateral inguinal sentinel lymph node biopsy, and radioguided breast resection (radioguided occult lesion localization) of the microcalcifications. The definitive histology revealed negative inguinal sentinel nodes, no further residual tumor in the vulva, and a high-grade (grade 3) DCIS in the breast. The synchronous occurrence of primary breast carcinoma and ectopic breast tissue carcinoma in the vulva is an extremely rare finding, only once previously being reported and leading to unsolved problems of differential diagnosis. The presence of a pure DCIS of the breast makes this case really unique, definitively confirming the independent primary origin of both mammary tumors. The inguinal sentinel node biopsy avoided a bilateral inguinal dissection.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume16
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Breast cancer
  • Carcinoma of the vulva
  • DCIS
  • Ectopic breast cancer
  • Inguinal sentinel node biopsy
  • Lymphoscintigraphy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Cancer Research

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