A rare bone-leptomeningeal metastasis from an adrenal cortical carcinoma

Gennaro Capone, Giuseppe Maria Della Pepa, Giovanni Sabatino, Elena Bartoccioni, Alessio Albanese, Stefano Mannino, Giulio Maira

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We report a rare bone-leptomeningeal metastasis from an adrenal cortical carcinoma (ACC). ACC is a rare malignancy and represents one of the most unusual sources of intracranial metastases (0-0.2%); the localization to the skull bone and meninges is uncommon. A 45-year-old man underwent surgery for a non-functioning ACC; 4 months later he developed a soft left frontal mass. The CT scans and MRI showed a large tumor with bone and leptomeningeal involvement. Despite chemotherapy, the lesion increased in volume, which led to local pain and right hemiparesis. Thus, the patient underwent excision of the mass; histopathological diagnosis confirmed that it was an ACC metastasis. The patient underwent standard radiation therapy after surgery. At post-operative follow-up, the patient was in a good neurological condition with no radiological evidence of a cranial recurrence; however, there was a voluminous abdominal regrowth of the primary tumor. To our knowledge, this is the second case of bone and leptomeningeal metastasis arising from an ACC. This patient report confirms the effectiveness of aggressive surgery for management of large intracranial metastases, particularly those that arise from primary tumors that are resistant to radiotherapy and chemotherapy. In our opinion, surgery represents the most appropriate treatment for voluminous intracranial metastasis - even when there are no neurological signs.

Original languageEnglish
Pages (from-to)977-980
Number of pages4
JournalJournal of Clinical Neuroscience
Issue number7
Publication statusPublished - Jul 2009


  • Adrenal cortical carcinoma
  • Metastasis
  • Skull neoplasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)


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