A Rare Case of Colic Thrombotic Microangiopathy in Renal Transplantation

V. Rizza, G. Coletti, C. Mazzotta, K. Clemente, P. Di Cocco, F. Del Reno, G. Margiotta, A. Famulari, F. Pisani

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We report a case of thrombotic microangiopathy (TM) in patient with UC and kidney transplantation. Case Report: A 59-year-old Caucasian may with a renal transplant, with atrial fibrillation and ulcerative colitis (UC), was referred for asthenia, fever (38°C), anemia, colicky pain, and bloody diarrhea. The maintenance therapy consisted of CSA, sodium mycophenolate, steroids, ticlopidine, and mesalazine. Laboratory data, colonscopy, and colic mucosal biopsy revealed de novo colic TM. We administered antibiotics and antishock therapy, reducing CSA, withdrawing ticlopedine and maintaining mesalazine with the resolution of the problem. Conclusion: Posttransplantation TM is an uncommon but severe complication of kidney transplantation associated with reduced graft survival and a high risk for death. Only an early, accurate diagnosis with optimal treatment permits resolution of the problem.

Original languageEnglish
Pages (from-to)1362-1364
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number4
DOIs
Publication statusPublished - May 2010

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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