A rare case of human pulmonary dirofilariasis with nodules mimicking malignancy: Approach to diagnosis and treatment

Paolo Albino Ferrari, Antonella Grisolia, Stefano Reale, Rosa Liotta, Alessandra Mularoni, Alessandro Bertani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Human pulmonary dirofilariasis is a rare zoonosis caused by the dog worm Dirofilaria spp., a parasite transmitted by mosquitos and resulting in peripheral lung nodules. The filarial nematode enters the subcutaneous tissue, travels to the right ventricle and dies causing a small pulmonary infarction that may embolize through the pulmonary vessels and may appear as a solitary nodule. These nodules are usually incidentally identified in asymptomatic patients undergoing chest imaging studies, and are generally interpreted to be malignant. Case presentation: We present the case report of a human dirofilariasis in a patient with multiple pulmonary nodules resected using video-assisted thoracic surgery (VATS). According to our literature review, this is the first case with double synchronous lung nodules reported in Italy. Conclusions: Minimally invasive resection with histologic examination may be the best approach for the diagnosis and treatment of pulmonary dirofilariasis. Polymerase Chain Reaction testing may provide a more accurate etiological diagnosis in case of an inconclusive pathology result.

Original languageEnglish
Article number65
JournalJournal of Cardiothoracic Surgery
Volume13
Issue number1
DOIs
Publication statusPublished - Jun 11 2018

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Dirofilariasis
Lung
Neoplasms
Dirofilaria
Multiple Pulmonary Nodules
Pulmonary Infarction
Right to Die
Therapeutics
Video-Assisted Thoracic Surgery
Subcutaneous Tissue
Zoonoses
Culicidae
Italy
Heart Ventricles
Parasites
Thorax
Dogs
Pathology
Polymerase Chain Reaction

Keywords

  • Lung nodules
  • PCR
  • Pulmonary dirofilariasis
  • Video-assisted thoracic surgery

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

A rare case of human pulmonary dirofilariasis with nodules mimicking malignancy : Approach to diagnosis and treatment. / Ferrari, Paolo Albino; Grisolia, Antonella; Reale, Stefano; Liotta, Rosa; Mularoni, Alessandra; Bertani, Alessandro.

In: Journal of Cardiothoracic Surgery, Vol. 13, No. 1, 65, 11.06.2018.

Research output: Contribution to journalArticle

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