A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy

M. Pollicita, C. Alteri, M. C. Bellocchi, D. Armenia, L. Carioti, R. Salpini, L. Colagrossi, A. Battisti, M. Aragri, L. Fabeni, R. Mariani, M. Dalessandro, A. Ranelli, M. Paoloni, G. Parruti, C. F. Perno, V. Svicher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period: 2011-2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.

Original languageEnglish
JournalClinical Microbiology and Infection
DOIs
Publication statusAccepted/In press - Feb 23 2015

Fingerprint

Hepatitis B
Hepatitis B virus
Italy
Virus Diseases
Genotype
Infection
Coitus
Vaccination

Keywords

  • Acute infection
  • Epidemiological cluster
  • Genotype
  • HBV
  • Vaccine

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy. / Pollicita, M.; Alteri, C.; Bellocchi, M. C.; Armenia, D.; Carioti, L.; Salpini, R.; Colagrossi, L.; Battisti, A.; Aragri, M.; Fabeni, L.; Mariani, R.; Dalessandro, M.; Ranelli, A.; Paoloni, M.; Parruti, G.; Perno, C. F.; Svicher, V.

In: Clinical Microbiology and Infection, 23.02.2015.

Research output: Contribution to journalArticle

Pollicita, M, Alteri, C, Bellocchi, MC, Armenia, D, Carioti, L, Salpini, R, Colagrossi, L, Battisti, A, Aragri, M, Fabeni, L, Mariani, R, Dalessandro, M, Ranelli, A, Paoloni, M, Parruti, G, Perno, CF & Svicher, V 2015, 'A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy', Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2015.07.022
Pollicita, M. ; Alteri, C. ; Bellocchi, M. C. ; Armenia, D. ; Carioti, L. ; Salpini, R. ; Colagrossi, L. ; Battisti, A. ; Aragri, M. ; Fabeni, L. ; Mariani, R. ; Dalessandro, M. ; Ranelli, A. ; Paoloni, M. ; Parruti, G. ; Perno, C. F. ; Svicher, V. / A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy. In: Clinical Microbiology and Infection. 2015.
@article{7c412d81528a43058ceaa9ca26a62e7f,
title = "A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy",
abstract = "In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period: 2011-2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.",
keywords = "Acute infection, Epidemiological cluster, Genotype, HBV, Vaccine",
author = "M. Pollicita and C. Alteri and Bellocchi, {M. C.} and D. Armenia and L. Carioti and R. Salpini and L. Colagrossi and A. Battisti and M. Aragri and L. Fabeni and R. Mariani and M. Dalessandro and A. Ranelli and M. Paoloni and G. Parruti and Perno, {C. F.} and V. Svicher",
year = "2015",
month = "2",
day = "23",
doi = "10.1016/j.cmi.2015.07.022",
language = "English",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy

AU - Pollicita, M.

AU - Alteri, C.

AU - Bellocchi, M. C.

AU - Armenia, D.

AU - Carioti, L.

AU - Salpini, R.

AU - Colagrossi, L.

AU - Battisti, A.

AU - Aragri, M.

AU - Fabeni, L.

AU - Mariani, R.

AU - Dalessandro, M.

AU - Ranelli, A.

AU - Paoloni, M.

AU - Parruti, G.

AU - Perno, C. F.

AU - Svicher, V.

PY - 2015/2/23

Y1 - 2015/2/23

N2 - In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period: 2011-2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.

AB - In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period: 2011-2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.

KW - Acute infection

KW - Epidemiological cluster

KW - Genotype

KW - HBV

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=84941749971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941749971&partnerID=8YFLogxK

U2 - 10.1016/j.cmi.2015.07.022

DO - 10.1016/j.cmi.2015.07.022

M3 - Article

C2 - 26260987

AN - SCOPUS:84941749971

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

ER -