A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci

P. Magnaghi, A. Agazzi, O. Semino, M. Ferrari, T. Barbul, A. D'Angelo, R. Taramelli

Research output: Contribution to journalArticle

Abstract

Genetic studies as well as in situ hybridisation data have strongly demonstrated that the genes coding for apoprotein(a) and plasminogen are linked and localised to chromosome 6 at band 6q26-27. We describe in this report the presence of a recombination event in a region of approximately 50 kb of DNA separating the two genes. The recombination was found in an Italian family, in which a mutation affecting both plasminogen plasma level and activity of plasminogen activity has been detected. Polymerase chain reaction and sequencing analysis showed the presence of a mutation different from those previously reported in two Japanese families.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalClinical Genetics
Volume47
Issue number6
Publication statusPublished - 1995

Keywords

  • Apoprotein(a)
  • Gene cluster
  • Plasminogen
  • Recombination

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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