A record card for the study of neuronal hyperexcitability syndrome

Silvano Cristina, Giorgio Sandrini, Luigi Ruiz, Anna Pia Verri, Massimo Musicco, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review


Neuronal Hyperexcitability Syndrome (NHS) is a nosographic picture which is difficult to diagnose, due to the lack of specific standard diagnostic criteria. With slightly varying symptoms the syndrome has also been defined as Spasmophilia and Hyperventilation Syndrome. It is difficult to distinguish between NHS and panic attack disorder as there is considerable overlapping of symptomatology. We aimed to propose a standardized card which will be the first step toward a valid diagnosis of this complex neuropsychiatric problem. This card, which will be validated and of which the reliability will be evaluated, is proposed for clinical and research purposes. The card is made up of 6 parts (113 items) covering: personal data, pharmacological treatment, persistent diseases and related therapies, symptomatology trend, factors interfering with calcium magnesium homeostasis and symptom assessment. The symptom assessment section is essential for the checking of diagnostic criteria and the earlier sections are important for the monitoring of other factors which can cause symptoms able to simulate NHS. There are also two special sections for recording laboratory tests and patients' psychic profiles.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalFunctional Neurology
Issue number1
Publication statusPublished - Jan 1996


  • epidemiology
  • neuronal hyperexcitability syndrome
  • standardized card

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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