A recurrent 19q11-12 breakpoint suggested by cytogenetic and fluorescence in situ hybridization analysis of three glioblastoma cell lines

Ivana Magnani, Elena Chiariello, Anna Maria Fuhrman Conti, Gaetano Finocchiaro

Research output: Contribution to journalArticle

Abstract

Loss of genetic material at chromosome 19 is a rather frequent finding in malignant gliomas. Loss of heterozygosity at region 19q13.3 is common in oligodendrogliomas and is also present, together with other genetic alterations on the same chromosome, in glioblastoma multiforme (GBM). Here we describe the results of cytogenetic and fluorescence in situ hybridization analysis on three GBM cell lines in which a series of complex chromosomal rearrangements affecting chromosome 19 were present. These genetic alterations suggest the presence of a common breakpoint at 19q11-12 which may point to the localization of a fragile site and/or to the presence of tumor suppressor gene(s) in the pericentromeric region of chromosome 19.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume110
Issue number2
DOIs
Publication statusPublished - Apr 15 1999

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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