A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy

Sara Damiano, Patrizia Lombari, Erika Salvi, Massimo Papale, Antonio Giordano, Margherita Amenta, Gabriele Ballistreri, Simona Fabroni, Paolo Rapisarda, Giovambattista Capasso, Iris Maria Forte, Daniela Barone, Roberto Ciarcia

Research output: Contribution to journalArticle

Abstract

The major cause of end-stage renal disease is the diabetic nephropathy. Oxidative stress contributes to the development of type II diabetes mellitus (T2DM). In this study we have evaluated the effect of a diet with a new standardized of red orange and lemon extract (RLE) rich in anthocyanins (ANT) in the progression of the kidney disease on Zucker diabetic fatty rats. Oxidative stress and renal function were analyzed. In diabetic rats, the RLE restored the blood glucose levels, body weight, and normalized the reactive oxygen species (ROS) total pathways. The kidney inflammation, in diabetic rats, has not shown significant change, showing that the oxidative stress rather than to inflammatory processes is a triggering factor in the renal complication associated with T2DM. Therefore, the administration of the RLE prevents this complication and this effect could be related to the inhibition of ROS production.

Original languageEnglish
Pages (from-to)23268-23278
Number of pages11
JournalJournal of Cellular Physiology
Volume234
Issue number12
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Oxidative stress
Anthocyanins
Diabetic Nephropathies
Byproducts
Rats
Oxidative Stress
Kidney
Reactive Oxygen Species
Kidney Diseases
Nutrition
Medical problems
Type 2 Diabetes Mellitus
Chronic Kidney Failure
Blood Glucose
Body Weight
Diet
Inflammation

Keywords

  • anthocyanins
  • diabetic nephropathy
  • reactive oxygen species
  • renal micropuncture

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Damiano, S., Lombari, P., Salvi, E., Papale, M., Giordano, A., Amenta, M., ... Ciarcia, R. (2019). A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy. Journal of Cellular Physiology, 234(12), 23268-23278. https://doi.org/10.1002/jcp.28893

A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy. / Damiano, Sara; Lombari, Patrizia; Salvi, Erika; Papale, Massimo; Giordano, Antonio; Amenta, Margherita; Ballistreri, Gabriele; Fabroni, Simona; Rapisarda, Paolo; Capasso, Giovambattista; Forte, Iris Maria; Barone, Daniela; Ciarcia, Roberto.

In: Journal of Cellular Physiology, Vol. 234, No. 12, 01.01.2019, p. 23268-23278.

Research output: Contribution to journalArticle

Damiano, S, Lombari, P, Salvi, E, Papale, M, Giordano, A, Amenta, M, Ballistreri, G, Fabroni, S, Rapisarda, P, Capasso, G, Forte, IM, Barone, D & Ciarcia, R 2019, 'A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy', Journal of Cellular Physiology, vol. 234, no. 12, pp. 23268-23278. https://doi.org/10.1002/jcp.28893
Damiano, Sara ; Lombari, Patrizia ; Salvi, Erika ; Papale, Massimo ; Giordano, Antonio ; Amenta, Margherita ; Ballistreri, Gabriele ; Fabroni, Simona ; Rapisarda, Paolo ; Capasso, Giovambattista ; Forte, Iris Maria ; Barone, Daniela ; Ciarcia, Roberto. / A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy. In: Journal of Cellular Physiology. 2019 ; Vol. 234, No. 12. pp. 23268-23278.
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