A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

A. Marinelli; D. Bossi; P. G. Pelicci; S. Minucci

doi:10.1038/sj.leu.2404572

A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

A. Marinelli, D. Bossi, P. G. Pelicci, S. Minucci

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Alterations of the retinoic acid receptor (RAR)α locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARα chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARβ and RARγ), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARα locus in leukemia patients must occur - rather than through functional differences among the various RAR isoforms - as the consequence of the nuclear architecture of the different RAR loci.

Original language	English
Pages (from-to)	647-650
Number of pages	4
Journal	Leukemia
Volume	21
Issue number	4
DOIs	https://doi.org/10.1038/sj.leu.2404572
Publication status	Published - Apr 2007

ASJC Scopus subject areas

Hematology
Cancer Research

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abstract = "Alterations of the retinoic acid receptor (RAR)α locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARα chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARβ and RARγ), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARα locus in leukemia patients must occur - rather than through functional differences among the various RAR isoforms - as the consequence of the nuclear architecture of the different RAR loci.",

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A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

Abstract

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