A refined multiscale self-entropy approach for the assessment of cardiac control complexity: Application to long QT syndrome type 1 patients

Vlasta Bari, Giulia Girardengo, Andrea Marchi, Beatrice De Maria, Paul A. Brink, Lia Crotti, Peter J. Schwartz, Alberto Porta

Research output: Contribution to journalArticlepeer-review

Abstract

The study proposes the contemporaneous assessment of conditional entropy(CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE)decomposition, as a function of the time scale via refined multiscale CE (RMSCE) and sE(RMSsE) with the aim at gaining insight into cardiac control in long QT syndrome type 1(LQT1) patients featuring the KCNQ1-A341V mutation. CE was estimated via the corrected CE (CCE) and sE as the difference between the ShE and CCE. RMSCE and RMSsE were computed over the beat-to-beat series of heart period (HP) and QT interval derived from 24-hour Holter electrocardiographic recordings during daytime (DAY)and nighttime (NIGHT). LQT1 patients were subdivided into asymptomatic and symptomatic mutation carriers (AMCs and SMCs) according to the severity of symptoms and contrasted with non-mutation carriers (NMCs). We found that RMSCE and RMSsE carry non-redundant information, separate experimental conditions (i.e., DAY and NIGHT)within a given group and distinguish groups (i.e., NMC, AMC and SMC) assigned theb experimental condition. Findings stress the importance of the joint evaluation of RMSCE and RMSsE over HP and QT variabilities to typify the state of the autonomic functionand contribute to clarify differences between AMCs and SMCs.

Original languageEnglish
Pages (from-to)7768-7785
Number of pages18
JournalEntropy
Volume17
Issue number11
DOIs
Publication statusPublished - 2015

Keywords

  • Autonomic nervous system
  • Corrected conditional entropy
  • Heart rate variability
  • Information storage
  • KCNQ1-A341V mutation
  • LQT1
  • QT interval
  • Refined multiscale entropy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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