A relapsing inflammatory syndrome and active human herpesvirus 8 infection

Lorenzo Dagna; Francesco Broccolo; Carlo T. Paties; Marina Ferrarini; Loredana Sarmati; Luisa Praderio; Maria Grazia Sabbadini; Paolo Lusso; Mauro S. Malnati

doi:10.1056/NEJMoa042850

A relapsing inflammatory syndrome and active human herpesvirus 8 infection

Lorenzo Dagna, Francesco Broccolo, Carlo T. Paties, Marina Ferrarini, Loredana Sarmati, Luisa Praderio, Maria Grazia Sabbadini, Paolo Lusso, Mauro S. Malnati

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.

Original language	English
Pages (from-to)	156-163
Number of pages	8
Journal	New England Journal of Medicine
Volume	353
Issue number	2
DOIs	https://doi.org/10.1056/NEJMoa042850
Publication status	Published - Jul 14 2005

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJMoa042850

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A relapsing inflammatory syndrome and active human herpesvirus 8 infection. / Dagna, Lorenzo; Broccolo, Francesco; Paties, Carlo T.; Ferrarini, Marina; Sarmati, Loredana; Praderio, Luisa; Sabbadini, Maria Grazia; Lusso, Paolo; Malnati, Mauro S.

In: New England Journal of Medicine, Vol. 353, No. 2, 14.07.2005, p. 156-163.

Research output: Contribution to journal › Article › peer-review

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AU - Broccolo, Francesco

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AU - Ferrarini, Marina

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AU - Praderio, Luisa

AU - Sabbadini, Maria Grazia

AU - Lusso, Paolo

AU - Malnati, Mauro S.

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