TY - JOUR
T1 - A report of six cases of familial papillary thyroid cancer
AU - Orsenigo, Elena
AU - Beretta, Edoardo
AU - Gini, Paola
AU - Verrecchia, Francesco
AU - Invernizzi, Laura
AU - Fiorina, Paolo
AU - Di Carlo, Valerio
PY - 2003/3
Y1 - 2003/3
N2 - Aims: Familial occurrence of papillary thyroid cancer is uncommon. The purpose of this study was review our own experience in a series of 267 papillary thyroid cancers. Methods: We analysed the clinical records of 267 consecutive patients operated on for papillary thyroid cancer (PTC) in our hospital between June 1980-March 2000. Results: We identified a family history in three families (6 patients), which results in a 2.25% familial papillary thyroid carcinoma (FPTC) rate. Pathology findings revealed that the tumour was multifocal and bilateral in 2 patients. Lymph-node metastases were found in 4 patients. They are all alive with a mean time of follow-up of 74.3 months (range 2-120). Conclusions: We recommend that patients with familial disease should be treated according to the disease stage and other risk factors, similar to those with sporadic differentiated papillary thyroid cancer. We encourage the further reporting and pedigree analysis to identify patients affected by FPTC.
AB - Aims: Familial occurrence of papillary thyroid cancer is uncommon. The purpose of this study was review our own experience in a series of 267 papillary thyroid cancers. Methods: We analysed the clinical records of 267 consecutive patients operated on for papillary thyroid cancer (PTC) in our hospital between June 1980-March 2000. Results: We identified a family history in three families (6 patients), which results in a 2.25% familial papillary thyroid carcinoma (FPTC) rate. Pathology findings revealed that the tumour was multifocal and bilateral in 2 patients. Lymph-node metastases were found in 4 patients. They are all alive with a mean time of follow-up of 74.3 months (range 2-120). Conclusions: We recommend that patients with familial disease should be treated according to the disease stage and other risk factors, similar to those with sporadic differentiated papillary thyroid cancer. We encourage the further reporting and pedigree analysis to identify patients affected by FPTC.
KW - Familial papillary thyroid cancer
KW - HLA
KW - Total thyroidectomy
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U2 - 10.1053/ejso.2002.1345
DO - 10.1053/ejso.2002.1345
M3 - Article
C2 - 12633563
AN - SCOPUS:0037350137
VL - 29
SP - 185
EP - 187
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 2
ER -