A retrospective analysis of 3 156 admissions with fever of unknown origin in a large Italian hospital

Nicola Nicolotti, Caterina Cattel, Maria Rosaria Gualano, Alessandra Soriano, Raffaele Manna, Stefania Boccia

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Abstract

Background: fever of unknown origin (FUO) is defined as a fever with no etiologic diagnosis after standardized investigations performed during 3 days in hospital or after at least 3 ambulatory visits. Our study aims to describe the epidemiology of classic FUO through the retrospective analysis of 902 861 admissions to a large University Hospital in Italy, to investigate its temporal trend, and to evaluate differences between young and old patients. Methods: we retrieved data records of all the admissions between the 1st January 1988 and 31st December 2007. Proportional admission rate (PAR) of FUO was calculated. Time trends of FUO admissions were analysed by joinpoint regression, with time changes expressed as Expected Annual Percent Change (EA PC). The ICD 9-CM code was used to identify the diagnosis on discharge of FUO cases. Results: in the study period 3 156 patients were admitted with a diagnosis of FUO (PAR=3.50 per 1 000). The time-trend analysis showed two joinpoints, the first in 1995 (EAPC of 307.80, 95% CI: 89.66-776.84, p=0.002), and the second in 1998 (EAPC=-8.57, 95% CI: -10.37-6.73; p

Original languageEnglish
Article numbere8776
JournalEpidemiology Biostatistics and Public Health
Volume10
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Epidemiology
  • Fever of unknown origin
  • Hospitals
  • Trends

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Community and Home Care

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