A retrospective analysis of postradiation chemotherapy in 133 patients with glioblastoma multiforme

Michele Reni, Cesare Cozzarini, A. J M Ferreri, Giovanni L. Ceresoli, Laura Galli, Alessandra Bianchi, Eugenio Villa

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Abstract

The impact on survival of postradiation nitrosourea-containing chemotherapy (CHT) in patients with glioblastoma multiforme (GM) was analyzed retrospectively in 133 patients who completed the planned radiotherapy out of 173 observed cases. Thirty-five patients were 60 Gy, and CHT had an independent prognostic value. Our results suggest that chemotherapy improves 2-year survival rates from 12% to 28% in GM. The sequence of treatment, new drugs, and combinations should be further explored.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalCancer Investigation
Volume18
Issue number6
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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