A retrospective evaluation of the etiology of unilateral vocal fold paralysis over the last 25 years

Giovanna Cantarella, Philippe Dejonckere, Anna Galli, Annaclara Ciabatta, Michele Gaffuri, Lorenzo Pignataro, Sara Torretta

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Previous studies have shown that the etiology of laryngeal paralysis has changed over the last decades, with an increase in the incidence of cases attributable to thyroid surgery. The aim of this study was to evaluate longitudinal changes in the etiology of unilateral vocal fold paralysis (UVFP) in a single institution over the last 25 years. This retrospective study analyzed the etiology of UVFP between 1990 and 2015 by comparing a cohort of patients treated in 1990–1992 with a cohort treated in 2013–2015. The final analysis was based on data concerning 356 patients (38.8 % males; mean age 55.3 ± 20.4 years): 113 in the 1990–1992 cohort, and 243 in the 2013–2015 cohort. The main cause of UVFP in the population as a whole was thyroidectomy (41.3 %), followed by an idiopathic origin (25.3 %) and thoracic surgery (12.1 %); this was confirmed in both intra-group analyses. There was a statistically significant association between etiology and the sub-group periods: the prevalence of post-thyroidectomy UVFP was highly significantly lower in the 2013–2015 cohort (35.4 vs 54.0 %), and the prevalence of idiopathic cases was higher (28.4 vs 18.6 %). Etiology significantly related to gender in both cohorts (p value ≤0.001). In the 2013–2015 cohort, there was also a statistically significant relationship between etiology and age classes (p value 0.017), and the left side was more frequently affected than the right (67.1 vs 32.9 %). Our findings document changes in the etiological pattern of UVFP over the last 25 years, with a considerable decrease in post-thyroidectomy UVFP, and a growing predominance of idiopathic and post-thoracic surgery UVFP.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume274
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Vocal Cords
Paralysis
Thyroidectomy
Thoracic Surgery
Vocal Cord Paralysis
Thyroid Gland
Retrospective Studies
Incidence
Population

Keywords

  • Etiology
  • Larynx
  • Thyroidectomy
  • Unilateral vocal fold paralysis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

A retrospective evaluation of the etiology of unilateral vocal fold paralysis over the last 25 years. / Cantarella, Giovanna; Dejonckere, Philippe; Galli, Anna; Ciabatta, Annaclara; Gaffuri, Michele; Pignataro, Lorenzo; Torretta, Sara.

In: European Archives of Oto-Rhino-Laryngology, Vol. 274, No. 1, 2017, p. 347-353.

Research output: Contribution to journalArticle

@article{b88b252705064678a6440c852c041604,
title = "A retrospective evaluation of the etiology of unilateral vocal fold paralysis over the last 25 years",
abstract = "Previous studies have shown that the etiology of laryngeal paralysis has changed over the last decades, with an increase in the incidence of cases attributable to thyroid surgery. The aim of this study was to evaluate longitudinal changes in the etiology of unilateral vocal fold paralysis (UVFP) in a single institution over the last 25 years. This retrospective study analyzed the etiology of UVFP between 1990 and 2015 by comparing a cohort of patients treated in 1990–1992 with a cohort treated in 2013–2015. The final analysis was based on data concerning 356 patients (38.8 {\%} males; mean age 55.3 ± 20.4 years): 113 in the 1990–1992 cohort, and 243 in the 2013–2015 cohort. The main cause of UVFP in the population as a whole was thyroidectomy (41.3 {\%}), followed by an idiopathic origin (25.3 {\%}) and thoracic surgery (12.1 {\%}); this was confirmed in both intra-group analyses. There was a statistically significant association between etiology and the sub-group periods: the prevalence of post-thyroidectomy UVFP was highly significantly lower in the 2013–2015 cohort (35.4 vs 54.0 {\%}), and the prevalence of idiopathic cases was higher (28.4 vs 18.6 {\%}). Etiology significantly related to gender in both cohorts (p value ≤0.001). In the 2013–2015 cohort, there was also a statistically significant relationship between etiology and age classes (p value 0.017), and the left side was more frequently affected than the right (67.1 vs 32.9 {\%}). Our findings document changes in the etiological pattern of UVFP over the last 25 years, with a considerable decrease in post-thyroidectomy UVFP, and a growing predominance of idiopathic and post-thoracic surgery UVFP.",
keywords = "Etiology, Larynx, Thyroidectomy, Unilateral vocal fold paralysis",
author = "Giovanna Cantarella and Philippe Dejonckere and Anna Galli and Annaclara Ciabatta and Michele Gaffuri and Lorenzo Pignataro and Sara Torretta",
year = "2017",
doi = "10.1007/s00405-016-4225-9",
language = "English",
volume = "274",
pages = "347--353",
journal = "European Archives of Oto-Rhino-Laryngology",
issn = "0937-4477",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - A retrospective evaluation of the etiology of unilateral vocal fold paralysis over the last 25 years

AU - Cantarella, Giovanna

AU - Dejonckere, Philippe

AU - Galli, Anna

AU - Ciabatta, Annaclara

AU - Gaffuri, Michele

AU - Pignataro, Lorenzo

AU - Torretta, Sara

PY - 2017

Y1 - 2017

N2 - Previous studies have shown that the etiology of laryngeal paralysis has changed over the last decades, with an increase in the incidence of cases attributable to thyroid surgery. The aim of this study was to evaluate longitudinal changes in the etiology of unilateral vocal fold paralysis (UVFP) in a single institution over the last 25 years. This retrospective study analyzed the etiology of UVFP between 1990 and 2015 by comparing a cohort of patients treated in 1990–1992 with a cohort treated in 2013–2015. The final analysis was based on data concerning 356 patients (38.8 % males; mean age 55.3 ± 20.4 years): 113 in the 1990–1992 cohort, and 243 in the 2013–2015 cohort. The main cause of UVFP in the population as a whole was thyroidectomy (41.3 %), followed by an idiopathic origin (25.3 %) and thoracic surgery (12.1 %); this was confirmed in both intra-group analyses. There was a statistically significant association between etiology and the sub-group periods: the prevalence of post-thyroidectomy UVFP was highly significantly lower in the 2013–2015 cohort (35.4 vs 54.0 %), and the prevalence of idiopathic cases was higher (28.4 vs 18.6 %). Etiology significantly related to gender in both cohorts (p value ≤0.001). In the 2013–2015 cohort, there was also a statistically significant relationship between etiology and age classes (p value 0.017), and the left side was more frequently affected than the right (67.1 vs 32.9 %). Our findings document changes in the etiological pattern of UVFP over the last 25 years, with a considerable decrease in post-thyroidectomy UVFP, and a growing predominance of idiopathic and post-thoracic surgery UVFP.

AB - Previous studies have shown that the etiology of laryngeal paralysis has changed over the last decades, with an increase in the incidence of cases attributable to thyroid surgery. The aim of this study was to evaluate longitudinal changes in the etiology of unilateral vocal fold paralysis (UVFP) in a single institution over the last 25 years. This retrospective study analyzed the etiology of UVFP between 1990 and 2015 by comparing a cohort of patients treated in 1990–1992 with a cohort treated in 2013–2015. The final analysis was based on data concerning 356 patients (38.8 % males; mean age 55.3 ± 20.4 years): 113 in the 1990–1992 cohort, and 243 in the 2013–2015 cohort. The main cause of UVFP in the population as a whole was thyroidectomy (41.3 %), followed by an idiopathic origin (25.3 %) and thoracic surgery (12.1 %); this was confirmed in both intra-group analyses. There was a statistically significant association between etiology and the sub-group periods: the prevalence of post-thyroidectomy UVFP was highly significantly lower in the 2013–2015 cohort (35.4 vs 54.0 %), and the prevalence of idiopathic cases was higher (28.4 vs 18.6 %). Etiology significantly related to gender in both cohorts (p value ≤0.001). In the 2013–2015 cohort, there was also a statistically significant relationship between etiology and age classes (p value 0.017), and the left side was more frequently affected than the right (67.1 vs 32.9 %). Our findings document changes in the etiological pattern of UVFP over the last 25 years, with a considerable decrease in post-thyroidectomy UVFP, and a growing predominance of idiopathic and post-thoracic surgery UVFP.

KW - Etiology

KW - Larynx

KW - Thyroidectomy

KW - Unilateral vocal fold paralysis

UR - http://www.scopus.com/inward/record.url?scp=84979587773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979587773&partnerID=8YFLogxK

U2 - 10.1007/s00405-016-4225-9

DO - 10.1007/s00405-016-4225-9

M3 - Article

AN - SCOPUS:84979587773

VL - 274

SP - 347

EP - 353

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

SN - 0937-4477

IS - 1

ER -