A retrospective study of cutaneous drug reactions in an outpatient population

Francesco Drago, Ludovica Cogorno, Arianna Fay Agnoletti, Giulia Ciccarese, Aurora Parodi

Research output: Contribution to journalArticle

Abstract

Background Adverse cutaneous drug reactions (ACDR) are unexpected cutaneous changes occurring at drug dosages that are normally used for disease prophylaxis, diagnosis or treatment. Objective The aim of the study was to determine the clinical types of ACDR, the causative agents, the latency time between drug intake and onset of ACDR and the recovery time in an outpatient population.Method Ninety-five patients diagnosed with ACDR at the Department of Dermatology of the University of Genoa between 2003 and 2012 were retrospectively studied. Results Antimicrobials, especially cephalosporins, were the most responsible for ACDR, followed by non-steroidal anti-inflammatory drugs and antihypertensives. The most common clinical manifestations were exanthema (42.1 %), erythema multiforme (10.53 %) and vasculitis (9.53 %). Patients with peripheral eosinophilia showed a more severe clinical manifestation, they were treated with systemic therapies and their recovery time was longer. Conclusion It is important to have an appropriate clinical approach according to the ACDR severity degree. We think that eosinophilia may characterise severe cutaneous eruptions and that it should always be investigated when ACDR is suspected in order to manage the patient with the appropriate treatment.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalInternational Journal of Clinical Pharmacy
Volume37
Issue number5
DOIs
Publication statusPublished - Jun 7 2015

Keywords

  • Adverse effects
  • Drug reactions
  • Periperal eosinophilia
  • Therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmaceutical Science
  • Pharmacology
  • Toxicology
  • Pharmacy

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