A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice

A. Fusco, G. Portella, M. Grieco, G. Tajana, G. Di Minno, N. Polli, A. Pinto

Research output: Contribution to journalArticle

Abstract

Mice inoculated with an artificially constructed retrovirus carrying the middle T gene of polyomavirus develop acute myeloproliferative disease with severe thrombotic and hemorrhagic disorder and impaired platelet function. The megakaryocytic lineage appears to be a target for polyoma-murine leukemia virus infection and middle T gene expression. This newly described disease represents a unique model system for studying disorders of the megakaryocytic lineage.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalJournal of Virology
Volume62
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice'. Together they form a unique fingerprint.

  • Cite this

    Fusco, A., Portella, G., Grieco, M., Tajana, G., Di Minno, G., Polli, N., & Pinto, A. (1988). A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice. Journal of Virology, 62(1), 361-365.