A review of the effects of hypoxia, sleep deprivation and transcranial magnetic stimulation on EEG activity in humans: Challenges for drug discovery for Alzheimer's disease

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Francesco Infarinato, Olivier Blin, David Bartrés-Faz, Sophie L. Dix, Marina Bentivoglio, Andrea Soricelli, Regis Bordet, Paolo M. Rossini, Jill C. Richardson

Research output: Contribution to journalArticle

Abstract

Different kinds of challenge can alter cognitive process and electroencephalographic (EEG) rhythms in humans. This can provide an alternative paradigms to evaluate treatment effects in drug discovery. Here, we report recent findings on the effects of challenges represented by sleep deprivation (SD), transient hypoxia, and transcranial magnetic stimulation (TMS) in healthy volunteers on cognitive processes and EEG rhythms to build a knowledge platform for novel research for drug discovery in AD Alzheimer's disease (AD). Sleep pressure enhanced frontal delta rhythms (<4 Hz) during the night, while SD increased slow rhythms in the theta range (4-7 Hz), and reduced resting state alpha rhythms (8-12 Hz) after the following day. Furthermore, SD transiently affected cognitive performance. In contrast, transient experimental hypoxia induced abnormal posterior resting state delta and alpha rhythms in healthy volunteers that resemble the abnormal EEG rhythms typically recorded in AD patients. However, the relationship between the cognitive and EEG effects of such challenges is poorly understood. TMS reversibly interfered with higher brain functions during EEG recordings, but few studies have investigated the relationship between the cognitive and EEG effects of TMS. In conclusion, SD is the most mature challenge model for testing new drugs for AD. Future investigation is needed to better understand the opportunities offered by TMS and hypoxia challenges.

Original languageEnglish
Pages (from-to)501-518
Number of pages18
JournalCurrent Alzheimer Research
Volume11
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Alzheimer's disease
  • Drug research
  • Electroencephalography (EEG)
  • Hypoxia
  • IMI PharmaCog
  • Sleep deprivation
  • Transcranial magnetic stimulation (TMS)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

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