A review of the treatment of primary headaches. Part I: Migraine

M. Leone, L. Grazzi, D. D'Amico, F. Moschiano, G. Bussone

Research output: Contribution to journalArticlepeer-review


Finding the best treatment for a patient's migraine is often a problem in clinical practice since the condition is very common, often debilitating and may prove refractory to therapy. Over recent years, more effective migraine treatments have been found and validated, and the traditional remedies have undergone controlled testing. This article reviews the various therapies available for both the acute treatment and prevention of migraine. Treatments often effective against migraine attacks are: aspirin, analgesics, non steroid antiinflammatory drugs (NSAIDs), ergot derivatives and sumatriptan. Five main classes of prophylactic drug are currently used: beta-blockers, calcium antagonists, serotonin modulators, NSAIDs and ergot compounds. Biofeedback, one of the most efficacious non-pharmacological preventive treatments of migraine, is also discussed. The variables influencing the choice of acute and preventive treatments, including contriandications and drug availability, are also described in order to provide a practical and up-to-date guide to migraine therapy.

Original languageEnglish
Pages (from-to)577-586
Number of pages10
JournalItalian Journal of Neurological Sciences
Issue number8
Publication statusPublished - Nov 1995


  • Acute treatment
  • Biofeedback
  • Migraine
  • Prophylaxis
  • Status migrainosus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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