A revised day + 7 predictive score for transplant-related mortality: Serum cholinesterase, total protein, blood urea nitrogen, γ glutamyl transferase, donor type and cell dose

M. P. Sormani, R. Oneto, B. Bruno, M. Fiorone, T. Lamparelli, F. Gualandi, A. M. Raiola, A. Dominieto, M. T. Van Lint, F. Frassoni, P. Bruzzi, A. Bacigalupo

Research output: Contribution to journalArticle

Abstract

We have previously described a scoring system for patients undergoing hemopoietic stem cell transplantation (HSCT) based on day + 7 blood urea nitrogen (BUN) and serum bilirubin levels. We have revised that scoring system using a formal multivariate approach based on a training phase (305 patients) and a validation phase (217 patients). Day +7 BUN, serum cholinesterase (CHE), total proteins (TP), gamma glutamyl transferase (γGT), donor type and cell dose at transplant were included in the new score. The score distribution identified three groups of patients in the training set ( 75 percentile of the score) which were classified as low, intermediate and high risk. Their actuarial risk of transplant-related mortality (TRM) at 6 years was, respectively, 12, 38 and 60%. In the validation set the 6 year actuarial TRM was, respectively, 15, 40 and 69%. High risk patients had more graft-versus-host disease (GvHD) (P

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalBone Marrow Transplantation
Volume32
Issue number2
DOIs
Publication statusPublished - Jul 2003

Keywords

  • GvHD
  • Leukemia

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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