A RIDDle solved: Why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses

Eelco Van Anken, Andrea Orsi, Roberto Sitia

Research output: Contribution to journalArticle

Abstract

As they commit to plasma cell differentiation, B lymphocytes must swiftly gear up to produce and secrete huge amounts of antibodies. To develop their secretory capacity, B cells exploit a signaling pathway that is employed by all eukaryotic cells in response to endoplasmic reticulum stress. An article by Benhamron et al. in this issue of the European Journal of Immunology, [Eur. J. Immunol. 2014. 44: 867-876] sheds new light on why an intact IRE1/XBP-1 signaling relay is central to orchestrate the full-blown expansion of the secretory machinery needed for massive antibody production.

Original languageEnglish
Pages (from-to)641-645
Number of pages5
JournalEuropean Journal of Immunology
Volume44
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Antibody production
  • IRE1
  • Plasma cells
  • Regulated IRE1-dependent decay (RIDD)
  • Unfolded protein response
  • XBP-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'A RIDDle solved: Why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses'. Together they form a unique fingerprint.

  • Cite this