A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer

Silvia Dellapasqua; Vincenzo Bagnardi; Meredith M. Regan; Nicole Rotmensz; Mauro G. Mastropasqua; Giuseppe Viale; Eugenio Maiorano; Karen N. Price; Richard D. Gelber; Monica Castiglione-Gertsch; Aron Goldhirsch; Marco Colleoni

doi:10.1016/j.breast.2012.06.003

A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer

Silvia Dellapasqua, Vincenzo Bagnardi, Meredith M. Regan, Nicole Rotmensz, Mauro G. Mastropasqua, Giuseppe Viale, Eugenio Maiorano, Karen N. Price, Richard D. Gelber, Monica Castiglione-Gertsch, Aron Goldhirsch, Marco Colleoni

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.

Original language	English
Pages (from-to)	621-628
Number of pages	8
Journal	Breast
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.breast.2012.06.003
Publication status	Published - Oct 2012

Keywords

Breast cancer
Chemotherapy
Endocrine therapy
Histopathological features
Risk score

ASJC Scopus subject areas

Surgery

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Dellapasqua, S., Bagnardi, V., Regan, M. M., Rotmensz, N., Mastropasqua, M. G., Viale, G., Maiorano, E., Price, K. N., Gelber, R. D., Castiglione-Gertsch, M., Goldhirsch, A., & Colleoni, M. (2012). A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer. Breast, 21(5), 621-628. https://doi.org/10.1016/j.breast.2012.06.003

A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer. / Dellapasqua, Silvia; Bagnardi, Vincenzo; Regan, Meredith M.; Rotmensz, Nicole; Mastropasqua, Mauro G.; Viale, Giuseppe; Maiorano, Eugenio; Price, Karen N.; Gelber, Richard D.; Castiglione-Gertsch, Monica; Goldhirsch, Aron; Colleoni, Marco.

In: Breast, Vol. 21, No. 5, 10.2012, p. 621-628.

Research output: Contribution to journal › Article › peer-review

Dellapasqua, S, Bagnardi, V, Regan, MM, Rotmensz, N, Mastropasqua, MG, Viale, G, Maiorano, E, Price, KN, Gelber, RD, Castiglione-Gertsch, M, Goldhirsch, A & Colleoni, M 2012, 'A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer', Breast, vol. 21, no. 5, pp. 621-628. https://doi.org/10.1016/j.breast.2012.06.003

Dellapasqua, Silvia ; Bagnardi, Vincenzo ; Regan, Meredith M. ; Rotmensz, Nicole ; Mastropasqua, Mauro G. ; Viale, Giuseppe ; Maiorano, Eugenio ; Price, Karen N. ; Gelber, Richard D. ; Castiglione-Gertsch, Monica ; Goldhirsch, Aron ; Colleoni, Marco. / A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer. In: Breast. 2012 ; Vol. 21, No. 5. pp. 621-628.

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title = "A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer",

abstract = "Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.",

keywords = "Breast cancer, Chemotherapy, Endocrine therapy, Histopathological features, Risk score",

author = "Silvia Dellapasqua and Vincenzo Bagnardi and Regan, {Meredith M.} and Nicole Rotmensz and Mastropasqua, {Mauro G.} and Giuseppe Viale and Eugenio Maiorano and Price, {Karen N.} and Gelber, {Richard D.} and Monica Castiglione-Gertsch and Aron Goldhirsch and Marco Colleoni",

year = "2012",

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doi = "10.1016/j.breast.2012.06.003",

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AU - Dellapasqua, Silvia

AU - Bagnardi, Vincenzo

AU - Regan, Meredith M.

AU - Rotmensz, Nicole

AU - Mastropasqua, Mauro G.

AU - Viale, Giuseppe

AU - Maiorano, Eugenio

AU - Price, Karen N.

AU - Gelber, Richard D.

AU - Castiglione-Gertsch, Monica

AU - Goldhirsch, Aron

AU - Colleoni, Marco

PY - 2012/10

Y1 - 2012/10

N2 - Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.

AB - Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.

KW - Breast cancer

KW - Chemotherapy

KW - Endocrine therapy

KW - Histopathological features

KW - Risk score

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