TY - JOUR
T1 - A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer
AU - Dellapasqua, Silvia
AU - Bagnardi, Vincenzo
AU - Regan, Meredith M.
AU - Rotmensz, Nicole
AU - Mastropasqua, Mauro G.
AU - Viale, Giuseppe
AU - Maiorano, Eugenio
AU - Price, Karen N.
AU - Gelber, Richard D.
AU - Castiglione-Gertsch, Monica
AU - Goldhirsch, Aron
AU - Colleoni, Marco
PY - 2012/10
Y1 - 2012/10
N2 - Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.
AB - Purpose: To develop a Risk Score (RS) to predict distant recurrence among premenopausal women with node-negative endocrine-responsive early breast cancer. Methods: The Cox model was used to develop the RS using clinical and histopathological features from 378 women participating in the IBCSG Trial VIII who received endocrine therapy alone or following chemotherapy. The performance of the resulting model was validated on a cohort of 1005 patients from a single institution who received endocrine therapy alone. Results: In a multivariable analysis, the risk of distant recurrence was associated with tumor size, ER, Ki-67 and peritumoral vascular invasion. In the validation cohort, patients with high RS were at greater risk of distant recurrence compared to patients with low RS (HR, 17.41; 95% CI, 5.72-52.95). Conclusion: In premenopausal women with node-negative endocrine-responsive early breast cancer, the RS identifies patients at higher risk of distant recurrence.
KW - Breast cancer
KW - Chemotherapy
KW - Endocrine therapy
KW - Histopathological features
KW - Risk score
UR - http://www.scopus.com/inward/record.url?scp=84865991935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865991935&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2012.06.003
DO - 10.1016/j.breast.2012.06.003
M3 - Article
C2 - 22749924
AN - SCOPUS:84865991935
VL - 21
SP - 621
EP - 628
JO - Breast
JF - Breast
SN - 0960-9776
IS - 5
ER -