A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus

Sari E. Lauri, Zuner A. Bortolotto, Robert Nistico, David Bleakman, Paul L. Ornstein, David Lodge, John T R Isaac, Graham L. Collingridge

Research output: Contribution to journalArticlepeer-review

Abstract

Compared with NMDA receptor-dependent LTP, much less is known about the mechanism of induction of NMDA receptor-independent LTP; the most extensively studied form of which is mossy fiber LTP in the hippocampus. In the present study we show that Ca2+-induced Ca2+ release from intracellular stores is involved in the induction of mossy fiber LTP. This release also contributes to the kainate receptor-dependent component of the pronounced synaptic facilitation that occurs during high-frequency stimulation. We also present evidence that the trigger for this Ca2+ release is Ca2+ permeation through kainate receptors. However, these novel synaptic mechanisms can be bypassed when the Ca2+ concentration is raised (from 2 to 4 mM), via a compensatory involvement of L-type Ca2+ channels. These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity.

Original languageEnglish
Pages (from-to)327-341
Number of pages15
JournalNeuron
Volume39
Issue number2
DOIs
Publication statusPublished - Jul 17 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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