A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice

F. Errico, V. D'Argenio, F. Sforazzini, F. Iasevoli, M. Squillace, G. Guerri, F. Napolitano, T. Angrisano, A. Di Maio, S. Keller, D. Vitucci, A. Galbusera, L. Chiariotti, A. Bertolino, A. De Bartolomeis, F. Salvatore, A. Gozzi, A. Usiello

Research output: Contribution to journalArticle

Abstract

Pharmacogenetics may allow for a personalized treatment, but a combination with clinical variables may further enhance prediction. In particular, in the present paper, we investigated early partial improvement (EPI) defined as 20% or more improvement by rating scales 2weeks after treatment, in combination with selected gene variants as a predictor of treatment outcome in patients with major depressive disorder. Two randomized controlled trials with 168 Japanese depressed patients were used. A stepwise multiple linear regression model with HAM-D score change at week 6 as the dependent variable and genotypes, EPI, baseline HAM-D score, age and sex as independent variables was performed in paroxetine, fluvoxamine and milnacipran, respectively, to estimate the prediction of HAM-D change at week 6. In the paroxetine sample, only EPI (P

Original languageEnglish
Article numbere512
JournalTranslational Psychiatry
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience

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    Errico, F., D'Argenio, V., Sforazzini, F., Iasevoli, F., Squillace, M., Guerri, G., Napolitano, F., Angrisano, T., Di Maio, A., Keller, S., Vitucci, D., Galbusera, A., Chiariotti, L., Bertolino, A., De Bartolomeis, A., Salvatore, F., Gozzi, A., & Usiello, A. (2015). A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice. Translational Psychiatry, 5(2), [e512]. https://doi.org/10.1038/tp.2015.2