Abstract
Background: Atopic dermatitis is associated with skin and blood eosinophilia, but the role of eosinophils in the pathogenesis of the skin lesions is poorly understood. Methods: To determine whether eosinophils play a role in the pathogenesis of the skin lesions in atopic dermatitis, we studied the relationship between the severity of the disease and both the number and the extent of activation of eosinophils in 15 patients with food-sensitive atopic dermatitis. Furthermore, this relationship was re-evaluated in eight of these patients who, after a period of elemental diet or total parenteral nutrition, showed significant clinical improvement. Results: A clear relationship was found between the number of light-density eosinophils and the severity of the disease both during the active disease and after clinical improvement. Furthermore, we describe an adhesion-stimulating activity for eosinophils in patients' plasma, which does not change after recovery. Conclusions: Taken together, these observations strongly indicate that eosinophils play a pivotal role in the pathogenesis of the skin lesions in atopic dermatitis. In particular, the light-density phenotype seems to be an essential feature of eosinophils involved in this process. The adhesion-promoting activity that we observed in the patients' plasma could be important in the recruitment of eosinophils from the blood into the skin. (J ALLERGY CLIN IMMUNOL 1995;96:200-8.).
| Original language | English |
|---|---|
| Pages (from-to) | 200-208 |
| Number of pages | 9 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- adhesion
- atopic dermatitis
- Eosinophil
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
A role for eosinophils in the pathogenesis of skin lesions in patients with food-sensitive atopic dermatitis. / Magnarin, Monica; Knowles, Alessandra; Ventura, Allessandro; Vita, Francesca; Fanti, Laura; Zabucchi, Giuliano.
In: Journal of Allergy and Clinical Immunology, Vol. 96, No. 2, 1995, p. 200-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A role for eosinophils in the pathogenesis of skin lesions in patients with food-sensitive atopic dermatitis
AU - Magnarin, Monica
AU - Knowles, Alessandra
AU - Ventura, Allessandro
AU - Vita, Francesca
AU - Fanti, Laura
AU - Zabucchi, Giuliano
PY - 1995
Y1 - 1995
N2 - Background: Atopic dermatitis is associated with skin and blood eosinophilia, but the role of eosinophils in the pathogenesis of the skin lesions is poorly understood. Methods: To determine whether eosinophils play a role in the pathogenesis of the skin lesions in atopic dermatitis, we studied the relationship between the severity of the disease and both the number and the extent of activation of eosinophils in 15 patients with food-sensitive atopic dermatitis. Furthermore, this relationship was re-evaluated in eight of these patients who, after a period of elemental diet or total parenteral nutrition, showed significant clinical improvement. Results: A clear relationship was found between the number of light-density eosinophils and the severity of the disease both during the active disease and after clinical improvement. Furthermore, we describe an adhesion-stimulating activity for eosinophils in patients' plasma, which does not change after recovery. Conclusions: Taken together, these observations strongly indicate that eosinophils play a pivotal role in the pathogenesis of the skin lesions in atopic dermatitis. In particular, the light-density phenotype seems to be an essential feature of eosinophils involved in this process. The adhesion-promoting activity that we observed in the patients' plasma could be important in the recruitment of eosinophils from the blood into the skin. (J ALLERGY CLIN IMMUNOL 1995;96:200-8.).
AB - Background: Atopic dermatitis is associated with skin and blood eosinophilia, but the role of eosinophils in the pathogenesis of the skin lesions is poorly understood. Methods: To determine whether eosinophils play a role in the pathogenesis of the skin lesions in atopic dermatitis, we studied the relationship between the severity of the disease and both the number and the extent of activation of eosinophils in 15 patients with food-sensitive atopic dermatitis. Furthermore, this relationship was re-evaluated in eight of these patients who, after a period of elemental diet or total parenteral nutrition, showed significant clinical improvement. Results: A clear relationship was found between the number of light-density eosinophils and the severity of the disease both during the active disease and after clinical improvement. Furthermore, we describe an adhesion-stimulating activity for eosinophils in patients' plasma, which does not change after recovery. Conclusions: Taken together, these observations strongly indicate that eosinophils play a pivotal role in the pathogenesis of the skin lesions in atopic dermatitis. In particular, the light-density phenotype seems to be an essential feature of eosinophils involved in this process. The adhesion-promoting activity that we observed in the patients' plasma could be important in the recruitment of eosinophils from the blood into the skin. (J ALLERGY CLIN IMMUNOL 1995;96:200-8.).
KW - adhesion
KW - atopic dermatitis
KW - Eosinophil
UR - http://www.scopus.com/inward/record.url?scp=0029123667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029123667&partnerID=8YFLogxK
U2 - 10.1016/S0091-6749(95)70009-9
DO - 10.1016/S0091-6749(95)70009-9
M3 - Article
C2 - 7636058
AN - SCOPUS:0029123667
VL - 96
SP - 200
EP - 208
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 2
ER -