A role for poly(ADP-ribosyl)ation in DNA methylation

Giuseppe Zardo, Anna Reale, Giovanna De Matteis, Serena Buontempo, Paola Caiafa

Research output: Contribution to journalArticle

Abstract

The aberrant DNA methylation of promoter regions of housekeeping genes leads to gene silencing. Additional epigenetic events, such as histone methylation and acetylation, also play a very important role in the definitive repression of gene expression by DNA methylation. If the aberrant DNA methylation of promoter regions is the starting or the secondary event leading to the gene silencing is still debated. Mechanisms controlling DNA methylation patterns do exist although they have not been ultimately proven. Our data suggest that poly(ADP-ribosyl)ation might be part of this control mechanism. Thus an additional epigenetic modification seems to be involved in maintaining tissue and cell-type methylation patterns that when formed during embryo development, have to be rigorously conserved in adult organisms.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalBiochemistry and Cell Biology
Volume81
Issue number3
DOIs
Publication statusPublished - Jun 2003

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Keywords

  • Chromatin
  • DNA methylation
  • Poly(ADP-ribosyl)ation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Zardo, G., Reale, A., De Matteis, G., Buontempo, S., & Caiafa, P. (2003). A role for poly(ADP-ribosyl)ation in DNA methylation. Biochemistry and Cell Biology, 81(3), 197-208. https://doi.org/10.1139/o03-050