A Role for the Action Observation Network in Apraxia After Stroke

Gloria Pizzamiglio, Zuo Zhang, James Kolasinski, Jane M. Riddoch, Richard E. Passingham, Dante Mantini, Elisabeth Rounis

Research output: Contribution to journalArticle

Abstract

Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right, and bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images to identify the neuroanatomical correlates of the impairment of performance in three tasks investigating praxis skills in patient populations. These included a meaningless gesture imitation task, a gesture production task involving pantomiming transitive and intransitive gestures, and a gesture recognition task involving recognition of these same categories of gestures. Neocortical lesions associated with poor performance in these tasks were all in the left hemisphere. They involved the pre-striate and medial temporal cortices, the superior temporal sulcus, inferior parietal area PGi, the superior longitudinal fasciculus underlying the primary motor cortex, and the uncinate fasciculus, subserving connections between temporal and frontal regions. No significant lesions were identified when language deficits, as indicated via a picture naming task, were controlled for. The implication of the superior temporal sulcus and the anatomically connected prestriate and inferior parietal regions challenges traditional models of the disorder. The network identified has been implicated in studies of action observation, which might share cognitive functions sub-serving praxis and language skills.

Original languageEnglish
Article number422
JournalFrontiers in Human Neuroscience
Volume13
DOIs
Publication statusPublished - Dec 20 2019

Fingerprint

Apraxias
Gestures
Temporal Lobe
Stroke
Observation
Language
Parietal Lobe
Aptitude
Motor Cortex
Task Performance and Analysis
Cognition
Extremities
Head
Population

Keywords

  • action observation
  • apraxia
  • gesture production
  • gesture recognition
  • meaningless gesture imitation
  • superior temporal sulcus
  • voxel-based lesion-symptom mapping

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Pizzamiglio, G., Zhang, Z., Kolasinski, J., Riddoch, J. M., Passingham, R. E., Mantini, D., & Rounis, E. (2019). A Role for the Action Observation Network in Apraxia After Stroke. Frontiers in Human Neuroscience, 13, [422]. https://doi.org/10.3389/fnhum.2019.00422

A Role for the Action Observation Network in Apraxia After Stroke. / Pizzamiglio, Gloria; Zhang, Zuo; Kolasinski, James; Riddoch, Jane M.; Passingham, Richard E.; Mantini, Dante; Rounis, Elisabeth.

In: Frontiers in Human Neuroscience, Vol. 13, 422, 20.12.2019.

Research output: Contribution to journalArticle

Pizzamiglio, G, Zhang, Z, Kolasinski, J, Riddoch, JM, Passingham, RE, Mantini, D & Rounis, E 2019, 'A Role for the Action Observation Network in Apraxia After Stroke', Frontiers in Human Neuroscience, vol. 13, 422. https://doi.org/10.3389/fnhum.2019.00422
Pizzamiglio, Gloria ; Zhang, Zuo ; Kolasinski, James ; Riddoch, Jane M. ; Passingham, Richard E. ; Mantini, Dante ; Rounis, Elisabeth. / A Role for the Action Observation Network in Apraxia After Stroke. In: Frontiers in Human Neuroscience. 2019 ; Vol. 13.
@article{e63ae50da4584b7797a1ea450ecc9698,
title = "A Role for the Action Observation Network in Apraxia After Stroke",
abstract = "Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right, and bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images to identify the neuroanatomical correlates of the impairment of performance in three tasks investigating praxis skills in patient populations. These included a meaningless gesture imitation task, a gesture production task involving pantomiming transitive and intransitive gestures, and a gesture recognition task involving recognition of these same categories of gestures. Neocortical lesions associated with poor performance in these tasks were all in the left hemisphere. They involved the pre-striate and medial temporal cortices, the superior temporal sulcus, inferior parietal area PGi, the superior longitudinal fasciculus underlying the primary motor cortex, and the uncinate fasciculus, subserving connections between temporal and frontal regions. No significant lesions were identified when language deficits, as indicated via a picture naming task, were controlled for. The implication of the superior temporal sulcus and the anatomically connected prestriate and inferior parietal regions challenges traditional models of the disorder. The network identified has been implicated in studies of action observation, which might share cognitive functions sub-serving praxis and language skills.",
keywords = "action observation, apraxia, gesture production, gesture recognition, meaningless gesture imitation, superior temporal sulcus, voxel-based lesion-symptom mapping",
author = "Gloria Pizzamiglio and Zuo Zhang and James Kolasinski and Riddoch, {Jane M.} and Passingham, {Richard E.} and Dante Mantini and Elisabeth Rounis",
year = "2019",
month = "12",
day = "20",
doi = "10.3389/fnhum.2019.00422",
language = "English",
volume = "13",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - A Role for the Action Observation Network in Apraxia After Stroke

AU - Pizzamiglio, Gloria

AU - Zhang, Zuo

AU - Kolasinski, James

AU - Riddoch, Jane M.

AU - Passingham, Richard E.

AU - Mantini, Dante

AU - Rounis, Elisabeth

PY - 2019/12/20

Y1 - 2019/12/20

N2 - Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right, and bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images to identify the neuroanatomical correlates of the impairment of performance in three tasks investigating praxis skills in patient populations. These included a meaningless gesture imitation task, a gesture production task involving pantomiming transitive and intransitive gestures, and a gesture recognition task involving recognition of these same categories of gestures. Neocortical lesions associated with poor performance in these tasks were all in the left hemisphere. They involved the pre-striate and medial temporal cortices, the superior temporal sulcus, inferior parietal area PGi, the superior longitudinal fasciculus underlying the primary motor cortex, and the uncinate fasciculus, subserving connections between temporal and frontal regions. No significant lesions were identified when language deficits, as indicated via a picture naming task, were controlled for. The implication of the superior temporal sulcus and the anatomically connected prestriate and inferior parietal regions challenges traditional models of the disorder. The network identified has been implicated in studies of action observation, which might share cognitive functions sub-serving praxis and language skills.

AB - Limb apraxia is a syndrome often observed after stroke that affects the ability to perform skilled actions despite intact elementary motor and sensory systems. In a large cohort of unselected stroke patients with lesions to the left, right, and bilateral hemispheres, we used voxel-based lesion-symptom mapping (VLSM) on clinical CT head images to identify the neuroanatomical correlates of the impairment of performance in three tasks investigating praxis skills in patient populations. These included a meaningless gesture imitation task, a gesture production task involving pantomiming transitive and intransitive gestures, and a gesture recognition task involving recognition of these same categories of gestures. Neocortical lesions associated with poor performance in these tasks were all in the left hemisphere. They involved the pre-striate and medial temporal cortices, the superior temporal sulcus, inferior parietal area PGi, the superior longitudinal fasciculus underlying the primary motor cortex, and the uncinate fasciculus, subserving connections between temporal and frontal regions. No significant lesions were identified when language deficits, as indicated via a picture naming task, were controlled for. The implication of the superior temporal sulcus and the anatomically connected prestriate and inferior parietal regions challenges traditional models of the disorder. The network identified has been implicated in studies of action observation, which might share cognitive functions sub-serving praxis and language skills.

KW - action observation

KW - apraxia

KW - gesture production

KW - gesture recognition

KW - meaningless gesture imitation

KW - superior temporal sulcus

KW - voxel-based lesion-symptom mapping

UR - http://www.scopus.com/inward/record.url?scp=85077390100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077390100&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2019.00422

DO - 10.3389/fnhum.2019.00422

M3 - Article

AN - SCOPUS:85077390100

VL - 13

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 422

ER -