A role for the TIM-3/GAL-9/BAT3 pathway in determining the clinical phenotype of multiple sclerosis

Marina Saresella, Federica Piancone, Ivana Marventano, Francesca La Rosa, Paola Tortorella, Domenico Caputo, Marco Rovaris, Mario Clerici

Research output: Contribution to journalArticle

Abstract

T-cell immunoglobulin and mucin domain 3 (Tim-3) ligates galectin-9 (Gal-9); this process, resulting in the inhibition of Th1 responses and in the apoptosis of antigen-specific cells, is hampered by binding of the molecular adaptor human leukocyte antigen B (HLA-B)-associated transcript 3 (Bat3) to the intracellular tail of Tim-3. Apoptosis of myelin basic protein (MBP)-specific T lymphocytes correlates with reduced rates of disease progression in multiple sclerosis (MS). We extensively analyzed the Tim-3/Gal-9/ Bat3 pathway in 87 patients with a diagnosis of stable relapsing-remitting MS (RRMS), primary progressive MS (PPMS), or benign MS (BEMS), as well as in 40 healthy control (HC) subjects. Results showed that MBP-specific CD4+Tim-3+, CD4+/Gal-9+, and CD4+/ Tim-3+/AV+ (apoptotic) T lymphocytes were augmented in the BEMS group, whereas CD4+/Bat3+and CD8+/Bat3+T lymphocytes were increased and CD4+/Tim-3+/AV+T cells were reduced in the PPMS group (>2 fold and P

Original languageEnglish
Pages (from-to)5000-5009
Number of pages10
JournalFASEB Journal
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Apoptosis
  • Myelin basic protein
  • T cell

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Fingerprint Dive into the research topics of 'A role for the TIM-3/GAL-9/BAT3 pathway in determining the clinical phenotype of multiple sclerosis'. Together they form a unique fingerprint.

  • Cite this