A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging

Valeria Catanzaro, Concetta V. Gringeri, Valeria Menchise, Sergio Padovan, Cinzia Boffa, Walter Dastrù, Linda Chaabane, Giuseppe Digilio, Silvio Aime

Research output: Contribution to journalArticlepeer-review

Abstract

Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.

Original languageEnglish
Pages (from-to)3926-3930
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number14
DOIs
Publication statusPublished - Apr 2 2013

Keywords

  • gadolinium
  • liposome
  • matrix metalloproteinases
  • molecular imaging
  • MRI probe

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

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