A brief rundown of coeliac disease: 1) the distant past, in which it was considered to be a rare, highly typical illness (diarrhoea, extreme loss of weight, swollen abdomen, with a prevalence of 1:10,000; 2) the revolution brought about by the "discovery" of autoantibodies, anti-endomysium and anti-transglutaminase, and the demonstration of the real prevalence of 1:200; 3) the progress in immuno-histochemical diagnosis in biopsies, and the increasingly felt opinion of doing away with biopsies for diagnosis; 4) recognition of the capacity of gluten to induce extra-intestinal auto-immune pathology; 5) the demonstration that the interruption of assumption of gluten interrupts the production of diabetes related autoantibodies; 6) finally, the study of the history of wheat as regards the history of coeliac disease in the world.
|Translated title of the contribution||A rundown of the facts (and words) in six items|
|Journal||Medico e Bambino|
|Issue number||7 SUPPL.|
|Publication status||Published - Sep 30 2002|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health