A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis

Rizza Stefano, Copetti Massimiliano, Cardellini Marina, Menghini Rossella, Pecchioli Chiara, Luzi Alessio, Di Cola Giovanni, Porzio Ottavia, Ippoliti Arnaldo, Romeo Franco, Pellegrini Fabio, Federici Massimo

Research output: Contribution to journalArticle

Abstract

Atherosclerosis disease is a leading cause for mortality and morbidity. The narrowing/rupture of a vulnerable atherosclerotic plaqueis accountable for acute cardiovascular events. However, despite of an intensive research, a reliable clinical method which may disclose a vulnerable patient is still unavailable. Approach and results: We tested the association of ADAM17 (A Disintegrin and Metallo Protease Domain 17) circulating substrates (sICAM-1, sVCAM-1, sIL6R and sTNFR1) with a second major cardiovascular events [MACEs] (cardiovascular death, peripheral artery surgeries, non-fatal myocardial infarction and non-fatal stroke) in 298 patients belonging to the Vascular Diabetes (AVD) study. To evaluate ADAM17 activity we create ADAM17 score through a RECPAM model. Finally we tested the discrimination ability and the reclassification of clinical models.At follow-up (mean 47 months, range 1-118 months), 55 MACEs occurred (14 nonfatal MI, 14 nonfatal strokes, 17 peripheral artery procedures and 10 cardiovascular deaths) (incidence=7.8% person-years). An increased risk for incident events was observed among the high ADAM17 score individuals both in univariable (HR 19.20, 95% CI 15.82-63.36, p

Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalAtherosclerosis
Volume239
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Keywords

  • ADAM17
  • Atherosclerosis
  • AVD
  • Cardiovascular disease outcomes
  • CEA
  • CV
  • Endothelium-derived factors
  • Follow up study
  • IDI
  • Inflammation
  • MACEs
  • NRI
  • OGTT
  • PTCA
  • RCHD
  • RECPAM
  • RIDI
  • TIMP3

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Stefano, R., Massimiliano, C., Marina, C., Rossella, M., Chiara, P., Alessio, L., Giovanni, D. C., Ottavia, P., Arnaldo, I., Franco, R., Fabio, P., & Massimo, F. (2015). A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis. Atherosclerosis, 239(2), 459-464. https://doi.org/10.1016/j.atherosclerosis.2015.01.029