A score of low-grade inflammation and risk of mortality: Prospective findings from the moli-sani study

Marialaura Bonaccio, Augusto Di Castelnuovo, George Pounis, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni De Gaetano, Licia Iacoviello, Licia Iacoviello, Maria Benedetta Donati, Giovanni De Gaetano, Jos Vermylen, Ignacio De Paula Carrasco, Simona Giampaoli, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Pasquale SpagnuoloDante Staniscia, Francesco Zito, Americo Bonanni, Chiara Cerletti, Amalia De Curtis, Augusto Di Castelnuovo, Licia Iacoviello, Roberto Lorenzet, Antonio Mascioli, Marco Olivieri, Domenico Rotilio, Augusto Di Castelnuovo, Marialaura Bonaccio, Simona Costanzo, Francesco Gianfagna, Marco Olivieri, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Amalia De Curtis, Federico Marracino, Maria Spinelli, Christian Silvestri, Americo Bonanni, Marialaura Bonaccio, Francesca De Lucia, Francesco Gianfagna, Branislav Vohnout, Franco Zito, General Coordinator, Mariarosaria Persichillo, Angelita Verna, Maura Di Lillo, Irene Di Stefano, Agostino Pannichella, Antonio Rinaldo Vizzarri, Branislav Vohnout, Agnieszka Pampuch, Antonella Arcari, Daniela Barbato, Francesca Bracone, Simona Costanzo, Carmine Di Giorgio, Sara Magnacca, Simona Panebianco, Antonello Chiovitti, Federico Marracino, Sergio Caccamo, Vanesa Caruso, Livia Rago, Daniela Cugino, Francesco Zito, Francesco Gianfagna, Alessandra Ferri, Concetta Castaldi, Marcella Mignogna, Tomasz Guszcz, Romina Di Giuseppe, Paola Barisciano, Lorena Buonaccorsi, Floriana Centritto, Antonella Cutrone, Francesca De Lucia, Francesca Fanelli, Iolanda Santimone, Anna Sciarretta, Maura Di Lillo, Isabella Sorella, Irene Di Stefano, Emanuela Plescia, Alessandra Molinaro, Christiana Cavone, Giovanna Galuppo, Maura Di Lillo, Concetta Castaldi, Dolores D’Angelo, Rosanna Ramacciato, Simona Costanzo, Simona Costanzo, Marco Olivieri, Livia Rago, Simona Costanzo, Amalia De Curtis, Licia Iacoviello, Mariarosaria Persichillo, Azienda Sanitaria Regionale Del Molise

Research output: Contribution to journalArticle

Abstract

Low-grade inflammation is associated with an increased risk of chronic degenerative disease, but its relationship with mortality is less well explored. We aimed at evaluating, at a large epidemiological level, the possible association of low-grade inflammation, as measured by a composite score, with overall mortality risk. We conducted a population-based prospective investigation on 20, 337 adult subjects free from major hematological disease and acute inflammatory status, randomly recruited from the general population of the Moli-sani study. A low-grade inflammation score was obtained from the sum of 10-tiles of plasmatic (C-reactive protein) and cellular (leukocyte and platelet counts, granulocyte/lymphocyte ratio) biomarkers of low-grade inflammation; higher levels indicated increased low-grade inflammation. Hazard ratios were calculated using multivariable Cox proportional hazard models with 95% confidence intervals. At the end of follow-up (median 7.6 years), 837 all-cause deaths were recorded. As compared to subjects in the lowest quartile of the low-grade inflammation score, those in the highest category had a significantly increased risk in overall mortality (HR=1.44; 1.17-1.77), independently of possible confounders, including the presence of chronic diseases and a number of health-related behaviors. The magnitude of the association of low-grade inflammation with mortality was relatively higher in type 2 diabetic patients (HR=2.90; 1.74-4.84) and in individuals with a history of cardiovascular disease (HR=2.48; 1.50-4.11) as compared to their counterparts who were free from the disease. In conclusion, an elevated degree of lowgrade inflammation, as measured by a composite score of inflammatory biomarkers, is an independent risk factor for total mortality in an apparently healthy adult general population.

Original languageEnglish
Pages (from-to)1434-1441
Number of pages8
JournalHaematologica
Volume101
Issue number11
DOIs
Publication statusPublished - Oct 31 2016

ASJC Scopus subject areas

  • Hematology

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    Bonaccio, M., Di Castelnuovo, A., Pounis, G., De Curtis, A., Costanzo, S., Persichillo, M., Cerletti, C., Donati, M. B., De Gaetano, G., Iacoviello, L., Iacoviello, L., Donati, M. B., De Gaetano, G., Vermylen, J., Carrasco, I. D. P., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., ... Molise, A. S. R. D. (2016). A score of low-grade inflammation and risk of mortality: Prospective findings from the moli-sani study. Haematologica, 101(11), 1434-1441. https://doi.org/10.3324/haematol.2016.144055