A search for double minute chromosomes in cultured lymphocytes from different types of tumors

Susi Scappaticci; Gian Silvio Fossati; Luigi Valenti; Matteo Scabini; Saverio Tateo; Giuseppe Nastasi; Maria Pompei Spina; Elena Capra

doi:10.1016/0165-4608(94)00288-M

A search for double minute chromosomes in cultured lymphocytes from different types of tumors

Susi Scappaticci, Gian Silvio Fossati, Luigi Valenti, Matteo Scabini, Saverio Tateo, Giuseppe Nastasi, Maria Pompei Spina, Elena Capra

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.

Original language	English
Pages (from-to)	50-53
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	82
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(94)00288-M
Publication status	Published - Jul 1 1995

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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AU - Scappaticci, Susi

AU - Fossati, Gian Silvio

AU - Valenti, Luigi

AU - Scabini, Matteo

AU - Tateo, Saverio

AU - Nastasi, Giuseppe

AU - Spina, Maria Pompei

AU - Capra, Elena

PY - 1995/7/1

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