Abstract
Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.
| Original language | English |
|---|---|
| Pages (from-to) | 50-53 |
| Number of pages | 4 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 82 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 1995 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
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A search for double minute chromosomes in cultured lymphocytes from different types of tumors. / Scappaticci, Susi; Fossati, Gian Silvio; Valenti, Luigi; Scabini, Matteo; Tateo, Saverio; Nastasi, Giuseppe; Spina, Maria Pompei; Capra, Elena.
In: Cancer Genetics and Cytogenetics, Vol. 82, No. 1, 01.07.1995, p. 50-53.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A search for double minute chromosomes in cultured lymphocytes from different types of tumors
AU - Scappaticci, Susi
AU - Fossati, Gian Silvio
AU - Valenti, Luigi
AU - Scabini, Matteo
AU - Tateo, Saverio
AU - Nastasi, Giuseppe
AU - Spina, Maria Pompei
AU - Capra, Elena
PY - 1995/7/1
Y1 - 1995/7/1
N2 - Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.
AB - Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.
UR - http://www.scopus.com/inward/record.url?scp=0029096706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029096706&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(94)00288-M
DO - 10.1016/0165-4608(94)00288-M
M3 - Article
C2 - 7627934
AN - SCOPUS:0029096706
VL - 82
SP - 50
EP - 53
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -