A search for double minute chromosomes in cultured lymphocytes from different types of tumors

Susi Scappaticci, Gian Silvio Fossati, Luigi Valenti, Matteo Scabini, Saverio Tateo, Giuseppe Nastasi, Maria Pompei Spina, Elena Capra

Research output: Contribution to journalArticle

Abstract

Double minutes are considered the products of DNA amplification and are rare in normal human cells. They have been observed in cultured lymphocytes in selected samples of human populations as one of the characteristics of the so-called rogue cells. We scored 9500 metaphases of cultured lymphocytes from 65 subjects with a variety of heredity and sporadic tumors and from 30 healthy subjects. The 15 cells with double minutes were found in subjects with multiple endocrine neoplasia type 1 (14 cases) and with familial adenomatous polyposis (1 case). Only one rogue cell was found among the 15 cells with double minutes.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume82
Issue number1
DOIs
Publication statusPublished - Jul 1 1995

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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