A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients

Robert Zivadinov, Tomas Uher, Jesper Hagemeier, Manuela Vaneckova, Deepa P. Ramasamy, Michaela Tyblova, Niels Bergsland, Zdenek Seidl, Michael G. Dwyer, Jan Krasensky, Eva Havrdova, Dana Horakova

Research output: Contribution to journalArticlepeer-review


Background: We explored the evolution of brain atrophy in relation to development of confirmed disability progression (CDP) on serial 1.5T magnetic resonance imaging (MRI) scans over a 10-year period in 181 patients with early relapsing-remitting multiple sclerosis (RRMS). Methods: At 10-year follow-up, they were divided into those with (100) or without (76) CDP (confirmed after 48 weeks). Changes in whole brain (WB), cortical, gray matter (GM), white matter, and ventricular cerebrospinal fluid (vCSF) volumes were calculated on three-dimensional T1-weighted (3D-T1) scans between all available time points. Results: In multiple sclerosis (MS) patients with CDP compared to those without, the greatest effect size percentage volume change from baseline to follow-up was detected for WB (d = 0.55, -7.5% vs -5.2%, p < 0.001), followed by vCSF (d = 0.51, +41.1% vs +25.7%, p < 0.001), cortical (d = 0.49, -7.7% vs -6.2%, p = 0.001), and GM (d = 0.40, -7.1% vs -5.8%, p = 0.006) volumes. Mixed-effects model analysis, adjusted for age, sex, and treatment change, showed significant interactions between CDP status and percentage changes for WB and vCSF (p < 0.001), cortical (p = 0.02), and GM (p = 0.04) volumes. Conclusions: WB and cortical atrophy, and enlargement of vCSF spaces are associated with development of CDP on serial yearly MRI assessments over a period of 10 years.

Original languageEnglish
Pages (from-to)1709-1718
Number of pages10
JournalMultiple Sclerosis
Issue number13
Publication statusPublished - Nov 1 2016


  • brain atrophy
  • disability progression
  • MRI
  • Multiple sclerosis
  • ventricular cerebrospinal fluid volume
  • whole brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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