A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer

Research output: Contribution to journalArticle

Abstract

Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalEMBO Molecular Medicine
Volume3
Issue number8
DOIs
Publication statusPublished - Aug 2011

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Keywords

  • Diagnosis
  • Early stage
  • Lung cancer
  • MiRNA
  • Serum

ASJC Scopus subject areas

  • Molecular Medicine

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